Coalitive effect

This would be a "coalitive" effect. Alternatively, "antagonism" may occur in which one substance decreases the toxic effect of another toxic agent. Thus, the overall toxic effect of the two compounds together maybe less than additive. 

Solvent abusers can die, sometimes after a single prolonged episode of sniffing, from either physical effects of the chemicals or dangerous behavior related to the user s impaired state of mind. The National Inhalant Prevention Coalition, a nonprofit organization based in Austin, Texas, records 100 to 125 deaths from inhalants... 

Organized groups of interest are an important function in today s society for they are able not only to influence the political agenda, but mainly because they do effectively have a surveillance function of the decisionmakers action. However, identification of these groups and even articulation of their interests is extremely important but it is not enough. There is often the need to put them in action for which effective coalition is needed. 

The CONEG legislation, which began to take effect in the early 1990s, has to do specifically with packaging materials. An acronym for Coalition of Northeastern Governors, CONEG prohibits the intentional addition of four heavy metals (mercury, lead, cadmium, and hexavalent chromium) into these materials at any level and sets the maximum incidental combined quantities for these metals as follows ... 

In humans the major and consistent effect is on the skin. Exposed people suffer from a severe form of acne, known as chloracne, after exposure to dioxin. Changes in the immune system have also been detected in the children exposed at Seveso in Italy and workers exposed at the Coalite plant in the UK. The latter had reduced levels of some immunoglobulins. There is no definitive evidence as to whether humans are more or less sensitive to dioxin than other mammals but the weight of evidence would suggest that they are less sensitive than many. 

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