CNS Neoplastic Diseases

The broad role that chemokines play in regulating development and function in the CNS appears to be recapitulated in their expression and activity in CNS tumors. CXCL12 (Barbero et al., 2002 Rubin et al, 2003), CXCLl 

The regulation of CXCR4 expression by factors known to be active in CNS tumors, such as Sonic hedgehog (Zhao et al, 2002), vascular ndothelial growth factor (Lee et al, 2002), the von Hippel-Lindau tumor suppressor pVHL (Staller et al., 2003), NF-kB (Helbig et al, 2003), and TNF-a 

Laschinger, M., and Engelhardt, B. (2002). Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 32, 2133-2144. 

Andrews, D. M., Matthews, V. B., Sammels, L. M., Carrello, A. C., and McMinn, P. C. (1999). The severity of murray valley eneephalids in mice is linked to neutrophil infiltration and inducible nitrie oxide synthase activity in the eentral nervous system. J. Virol. 73, 8781-8790. 

Bajetto, A., Bonavia, R., Barbero, S., Piecioli, P., Costa, A., Florio, T., and Schettini, G. (1999). Glial and neuronal eells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived faetor 1. J. Neurochem. 73, 2348-2357. 

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