CMGC kinases

CaMK kinases are Ca2+/calmodulin regulated kinases, while CMGC Pks collect cyclic-dependent, mitogene-activated peptide (MAP) kinases, GSK3 and Clk kinases, that phosphorylate substrates in proline-rich domains. The last group are PTKs (protein tyrosine kinases), which include both receptor and non-receptor kinases, which phosphorylates tyrosine residues (this will be discussed in Sect. 4.3). 

CMAP see correction maps CMGC group of kinases, % 186,192-194 CNS see central nervous system C02, 3,162,168... 

CMGC containing the Cyclin-dependent, Mitogen-activated, Glycogen synthase, and CDK-like kinases... 

Defined operationally as those kinases related to the CDK, MAPK, GSK3 and CLK families, this is the largest family of kinases in the Plasmodium kinome with 26 representatives in P. falciparum. With recognisable representatives of each sub-family of the greater CMGC family, (namely CDK [5 members], GSK3 [3 members], MAPK [2 members], CLK [4 members]), the pivotal role played by members of this family is underscored by the demonstration of apparent essentiality for most of these kinases in the P. berghei knock out study.15... 

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