Omeprazole clozapine

Substrates Inhibitors Inducers CYP1A2 Acetaminophen, caffeine, clozapine, imipramine, theophylline, propranolol Most fluoroquinolone antibiotics, fluvoxamine, cimetidine Tobacco smoking, charcoal-broiled foods, cruciferous vegetables, omeprazole... [Pg.355]

GFJ has been shown to increase the exposure of carbamazepine (175), cisapride (176-179), fluvoxamine (184), losartan (188), methadone (189), scopolamine (191), and sertraline (192). However, only the interaction of GFJ with carbamazepine and cisapride seems to be clinically relevant. No alteration in exposure was observed for clozapine (180,181), heophylline (195), halo-peridol (196), and omeprazole (190). Reports of increased pharmacokinetic parameters of clozapine, theophylline, and haloperidol suggest that an interaction is unlikely to be clinically relevant. Contradicting results were reported for itraconazole (185-187), digoxin (75,183), and sildenafil (193,194). An increased effect on concomitant use of diclofenac and GFJ was observed in rats (182). Overall, the clinical relevance for this drug class appears to be low. [Pg.176]

A2 Tertiary amine TCAs, duloxetine, theophylline, phenacetin, TCAs (demethylation), clozapine, diazepam, caffeine Fluvoxamine, fluoxetine, moclobemide, ramelteon Tobacco, omeprazole... [Pg.668]

Clozapine is mainly metabolized by CYP1A2, which is induced by the proton pump inhibitor omeprazole. In two patients co-medication with omeprazole and clozapine was associated with reduced plasma concentrations of clozapine of 42% and 45% (304). [Pg.280]

Frick A, Kopitz J, Bergemann N. Omeprazole reduces clozapine plasma concentrations. Pharmacopsychiatry 2003 36 121-3. [Pg.290]

ANTIPSYCHOTICS-CLOZAPINE PROTON PUMP INHIBITORS -OMEPRAZOLE Possible 1 efficacy of clozapine t metabolism via CYP1A2 Clinical significance unclear monitor more closely... [Pg.262]

A 43-year-old man took clozapine 750 mg/day for 6 years and developed vomiting and epigastric pain (145). He had ulcerative esophagitis, and a CT scan was reportedly normal apart from constipation. He was given omeprazole 20 mg/day and twice-daily psyllium. Six months later he developed abdominal... [Pg.831]

Arachidonic acid, benzo[a]pyrene, carbamazepine, clozapine, cyclophosphamide, S) and (R)-ibuprofen, omeprazole, paclitaxel, progesterone, retinoic acid, sulfadiazine, temazepam, testosterone, tienilic acid, trimethoprim, (J2)-warfarin, zidovudine Sulfafenazole Rifampicin... [Pg.468]

Ajmaline, alprenolol, amiflamine, amphetamine, aprindine, captopril, chlorpheniramine, cinnarizine, citalopram, clomipramine, clozapine, codeine, desipramine, dolasteron, encainide, flecainide, fluoxetine, fluphenazine, haloperidol, hydrocordone, imipramine, loratidine, methoxyphenamine, 3,4-methylenedioxymethamphetamine, metoprolol, mexiletine, (S)- and (i )-mianserin, nifedipine, olanzapine, omeprazole, oxycodone, perhexiline, phenformin, propaphenone, propranolol, remoxipride, ritonavir, saquinavir, selegiline, tamsulosin, timolol, tomoxetine, tramadol, trifluperidol, zolpidem... [Pg.470]

Acetaminophen, aldrin, alfentanil, amiodarone, aminopyrine, amitriptyline, amprenavir, androstenedione,antipyrine, astemizole, benzphetamine, budesonide, carbamazepine, celecoxib, chlorpromazine, chlorzoxazone, cisapride, clarithromycin, clozapine, cocaine, codeine, cortisol, cyclophosphamide,cyclosporin, dapsone, delavirdine, dextromethorphan, digitoxin, diltiazem, diazepam, erythromycin, 17j3-estradiol, ethinylestradiol, etoposide, felbamate, fentanyl, flutamide, hydroxyarginine, ifosphamide, imipramine, indinavir, ketoconazole, lansoprazole, loratidine, losartan, lovastatin, (iS)"mephen3d in, methadone, mianserin, miconazole, mifepristone, nelfinavir, nevirapine, nicardipine, nifedipine, odansetron, omeprazole, orphenadrine, proguanil, propafenone, quinidine, quinine, rapamycin, retinoic acid, ritonavir, saquinavir, selegiline, serindole, sufentanil, sulfinpyrazone, tacrolimus, tamoxifen, tamsulosin, taxol, teniposide, terfenadine, tetrahydrocannabinol, theophylline, toremifene, triazolam, trimethadone, trimethoprim, troleandomycin, verapamil, warfarin, zatosetron, Zolpidem, zonisamide... [Pg.471]

A2 Benzo[a]pyrene (from tobacco smoke), carbamazepine, phenobarbital, rifampin, omeprazole Acetaminophen, clozapine, haloperidol, theophylline, tricyclic antidepressants. (R)-warfarin... [Pg.35]

Omeprazole appears to reduce the serum levels of clozapine. [Pg.749]

A case report describes two patients (both smokers) whose clozapine levels were reduced, from 762 to 443 nanograms/mL and from 369 to 204 nanograms/mL, respectively, after omeprazole was started. However, no changes in clinicd condition were noted. ... [Pg.749]

MookhoekEJ, Loonen AJM. Retrospective evaluation of the effect of omeprazole on clozapine metabolism. Pharm WorldSci (2004) 26, 180-2. [Pg.749]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...