Clopidogrel Vasodilators

Flow cytometric determinations of P-selectin and activated GPIIb/llla receptor expression following ADP stimulation have been used to assess platelet inhibition by clopidogrel. Flow cytometry is also a cumbersome method and requires sophisticated instrumentation and well-trained technicians. The phosphorylation state of vasodilator-stimulated phos-phoprotein (VASP) is a specific intracellular marker of clopidogrel-induced P2Y 2 receptor inhibition and can also be measured by flow cytometry. Permeation of the membrane and the use of monoclonal antibodies specific for phosphory-lated VASP are required in this method (15,88). 

VASODILATOR ANTIHYPERTENSIVES CLOPIDOGREL t risk of bleeding when dopidogrel is co-administered with iloprost Uncertain at present Closely monitor the effects watch for signs of excess bleeding... 

CLOPIDOGREL PERIPHERAL VASODILATORS Possible t risk of bleeding with cilostazol Additive effect cilostazol has antiplatelet activity. Clopidogrel t the levels of a metabolite of cilostazol that has high antiplatelet activity, by a mechanism that is uncertain at present Warn the patient to report any signs of t bleeding... 

Gurbel PA, Bliden KP, Etherington A, Tantry US. Assessment of clopidogrel responsiveness measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. Thromb Res 2007 121 107—15. 

---