Clopidogrel neurology

ADP receptor inhibitors might be used in patients with coronary artery disease, in neurology, and in angiology. This chapter will mainly consider indications of ticlopidine and clopidogrel since these are the only two drugs currently available in the market. 

He was diagnosed with moderate hyperhomocysteinemia and treated with 2.0 mg folic acid daily. He continued to take warfarin and clopidogrel. After 1 month, his plasma total homocysteine level had decreased to 9 pmol/L. He had no further episodes of weakness or other neurological symptoms during the ensuing 12 months. 

A randomised blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348 1329-1339 Chimowitz MI, Kokkinos J, Strong J et al. (1995). The Warfarin-Aspirin Symptomatic Intracranial Disease Study. Neurology 45 1488-1493... 

Diener HC, Cunha L, Forbes C et al. (1996). European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. Journal of the Neurological Sciences 143 1-13 Diener HC, Bogousslavsky J, Brass LM et al. (2004). Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH) randomised double-blind placebo-controlled trial. 

Ischemic stroke TPA, heparin, ASA, clopidogrel, ticlopidine, dipyridamole and aspirin, warfarin, surgery Neurological worsening, bieeding, PT/APTT, INR, CBC... 

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