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Clones/cloning tissue plasminogen activator

Along with the production of insulin, many other medical uses have been achieved for recombinant DNA. This includes the production of erythropoetin, a hormone used to stimulate production of red blood cells in anemic people tissue plasminogen activator, an enzyme that dissolves blood clots in heart attack victims and antihemophilic human factor VIII, used to prevent and control bleeding for hemophiliacs. These three important genetically engineered proteins were all cloned in hamster cell cultures. [Pg.333]

Linked fucose has been found on the EGF domains of urokinase, tissue plasminogen activator (tPA), factor VII, and factor XII, attached to the consensus sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys. The fucosyltransferase responsible for the initiation of this type of gly-cosylation has been cloned [165]. On human (but not bovine) factor IX the tetrasaccharide Neu5Ac(o 2-6)Gal(jSl—4)GlcNAc( 81-3)Fuc(al-0)Ser (O Fig. 13d) was found [166,167]. In other FGF domains only Fuc(a l-0)Ser/Thr was detected. [Pg.1757]

See other pages where Clones/cloning tissue plasminogen activator is mentioned: [Pg.44]    [Pg.206]    [Pg.330]    [Pg.236]    [Pg.65]    [Pg.44]    [Pg.206]    [Pg.68]    [Pg.268]    [Pg.44]    [Pg.206]    [Pg.132]    [Pg.51]    [Pg.1256]    [Pg.166]    [Pg.24]    [Pg.51]    [Pg.144]    [Pg.310]    [Pg.76]    [Pg.310]    [Pg.190]    [Pg.84]    [Pg.752]    [Pg.1491]    [Pg.310]    [Pg.298]   
See also in sourсe #XX -- [ Pg.21 ]



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Tissue plasminogen activator

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