Clopidogrel clinical trials

The reported incidence of resistance to these drugs varies greatly, from less than 5% to 75%. In part this tremendous variation in incidence reflects the definition of resistance (recurrent thrombosis while on antiplatelet therapy vs in vitro testing), methods by which drug response is measured, and patient compliance. Several methods for testing aspirin and clopidogrel resistance in vitro are now FDA-approved however, their utility outside of clinical trials remains controversial. 

I 5 Kastrati A, Mehilli J, Schuhlen H, et al. Intracoronary stenting and antithrombotic regimen-rapid eariy action for coronary treatment study investigators. A clinical trial of abciximab in elective percutaneous coronary intervention after pretreatment with clopidogrel. N Engl J Med 2004 350 232-238. 

Mehilli J, Kastrati A, Schuhlen H, et al. Randomized clinical trial of abciximab in diabetic patients undergoing elective percutaneous coronary interventions after treatment with a high loading dose of clopidogrel. Circulation 2004 I 10 3627-3635. 

Although ticlopidine has the same mechanism of action as clopidogrel and possesses a similar molecular structure, the results of clinical trials among the two agents are strikingly different. The Swedish Ticlopidine Multicenter Study (STIMS) had determined that ticlopidine therapy (500 mg/day) was able to reduce total mortality in comparison to placebo in patients with intermittent claudication p =... 

Morais J, on behalf of die CAPRIE investigators. Use of concomitant medications in the CAPRIE trial clopidogrel is unlikely to be associated with clinically significant drug interactions. Eur Heart J 99%) 19 (Absttact Suppl) 5. 

Saw J. Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation 2003 108 921 1. 

The thienopyridines include clopidogrel, ticlopidine, and prosugel. Clopidogrel is the only member of this class in clinical use at this time. A second generation of this drug, Prosugel, is undergoing trials (27). Ticlopidine is not used... 

---