Cleavage of Non-Diversified Thioether Linkers

Cleavage protocols for the release of aliphatic molecules are very common [273,274]. There exist, for example, procedures for photolabile linkers, linkers that are thermally cleavable and linkers that release target structures upon addition of hydrogenating reagents. Linkers for these methodologies are of a different nature as a result of their need to fulfil special demands. 

Cleavage products from thioether Hnkers do not only depend on the natme of the Hnker and the cleavage procedure. Even slight differences concerning the loaded substrate itself can have an influence on the cleavage result as 

The Sucholeiki thioether linkage can be synthesized via a disulfide bond (NpSSMpact) and addition of benzylbromide 408 or alternatively via the chlorine derivative and following reaction with benzylmercaptan. Other syntheses start from thiols that are converted with electrophiles. 

A new method of releasing compounds from soHd supports is the appH-cation of Sml2 that has been used before, for example, to cleave ether bonds on solid supports (HASC linker) [278]. The group of Procter applied this idea 

Dithianes are known as protecting groups for safety-catch linkers [66] but they can also be used as Unker systems for the synthesis of either carbonyl-containing or aliphatic compounds. Bertini et al. [280] synthesized the first 

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