HASC linker

Scheme 55 Reductive cleavage of an oxygen HASC linker by Procter [39,40]...

Procter [41] has also utilized a sulfur HASC linker for the sohd-phase synthesis of oxindoles. Treatment of immobilized substrate 228 with Sml2 released oxindole 229 from the support in good overall yield (Scheme 57). 

A new method of releasing compounds from soHd supports is the appH-cation of Sml2 that has been used before, for example, to cleave ether bonds on solid supports (HASC linker) [278]. The group of Procter applied this idea... 

The development of suitable linkers is a continuous area of interest in solid-supported synthesis. Based on their previously explored traceless linking strategy using HASC (a-heteroatom-substituted carbonyl) linkers employing Smb, Procter and coworkers have demonstrated the use of a novel sulfur-based linker for the synthesis of the tetra-... 

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