Clausena excavata clausine

Clauszoline-K and dausine C (clauszoline-L) have been isolated from the stem bark of the Chinese medidnal plant Clausena excavata [72], Clausine M and dausine N have been found in the root bark of the same plant [73]. The bioassay-guided fractionation of the organic extract of Murraya siamensis, collected in Thailand, led to the isolation of siamenol, which shows HIV-inhibitory activity [74], A simple route to these 7-oxygenated carbazole alkaloids has been developed, based on a highly efficient palladium-catalyzed approach (Scheme 15.21) [75] (Table 15.4). 

This strategy was pursued in the natural carbazole clausine C (107), which was isolated from the stem bark of Clausena excavata, a wild shrub that has been claimed to be a useful folk medicine in the treatment of snake bites (Scheme 7.23) [32]. 

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