Classification toxicological

Aviado DM Toxicity of aerosol propellants in the respiratory and circulatory systems. X. Proposed classification. Toxicology 3 321-332, 1975... 

Health and Safety Factors (Toxicology). No special precautions are necessary in the handling of malonic acid beyond normal safe handling measures. Due to its acidity malonic acid is classified as a mild irritant (skin irritation, rabbits). The LD q value (oral, rats) for malonic acid is 2750 mg/kg. Transport classification RID/ADR, IMDG-Code, lATA/lCAO not restricted. 

Physiological Classifications of Contaminants. The physiological classification of air contaminants is difficult, because the type of action of many gases and vapors depends on concentrations (55). For example, a vapor at one concentration may exert its principal effect as an anesthetic but, at a lower concentration, the same vapor may iujure the nervous system, the hematopoietic (blood-forming) system, or some visceral organ (see Toxicology). 

The nature of a toxic effect and the probabiUty of its occurring are often related to the number of exposures. The classification of toxic effects, and descriptions of toxicology tests, may be dictated by the number of exposures that eUcit toxic effects. The following terms are convenient in this respect. 

Toxicity classification is based on recommended exposure limits provided by chemical suppliers. This rating is provisional and will be reviewed when toxicological testing is completed. 

In clinical chemistry, a great number of components are to be determined. These components may be classified according to their physiological fimction. In occupational toxicology, a division into functional chemical components may be a better classification. 

European Centre for Ecotoxicology and Toxicology of Chemicals, Contact Sensitisation Classification According to Potency, Tech. Rep. No. 87, Brussels, 2003. 

There have been several attempts over the years to classify adverse drug reactions, primarily based on the perception of what can and what cannot be predicted given knowledge of the pharmacology and toxicology of the drug. For example, Edwards and Aronson [13] proposed what is probably the most extensive classification system ... 

Fixed Dose Procedure. The fixed dose design (Figure 5.7) was proposed by the British Toxicology Society (1984). It is designed to supply the data needed for classification or labeling purposes. It is essentially a three-step limit test. 

British Toxicology Society (1984). A new approach to the classification of substances and preparations on the basis of their acute toxicity. A report by the British Toxicology Society Working Party on Toxicology. Human Toxicol. 3 85-92. 

The EPA has determined that endrin is not classified as to its human carcinogenicity (Group D) because the available information is inadequate to allow the classification (IRIS 1995). No cancer classifications exist for the IARC (no adequate data) (IARC 1987). The National Toxicology Program (NIP) has assigned endrin the carcinogen code N (negative) (NTP 1995). 

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