Classic phenotypic screening

Property Immortalized cells Primary cells iPSCs 

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As in classical genetics, a chemical genetic approach involves screening with probes that potentially could interact with any target in the genome, while trying to identify specific phenotypes. An alternate approach, termed reverse chemical... 

A recently introduced technique that also targets the phenotype is whole genome shuffling. This latter approach involves the amplification of the genetic diversity within a population through genetic recombination [19, 20]. Next, similar to the traditional procedure, the newly created library is screened for mutants with the desired properties. Its main advantage is that improvement is much faster than is possible with classical mutation and selection as described above. 

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