Citrate-based biodegradable elastomer

TABLE 16.1 Citrate-Based Biodegradable Elastomers Composition, Name, Properties, and Their Applications ... 

TABLE 16.2 Mechanical and Degradation Properties of Citrate-Based Biodegradable Elastomers and Some Selected Soft Tissues ... 

FIGURE 16.3 Diol and diacid monomers used in citrate-based biodegradable elastomers (CABEs) system. 

CABEs citrate-based biodegradable elastomers CABEs can be POC, BPLP, POMaC or POMC... 

FIGURE 16.6 Synthesis and cross-linking process of nrethane-doped citrate-based biodegradable elastomers (UCABEs). 

FIGURE 16.8 Two different strategies of the synthesis of NO-releasing citrate-based biodegradable elastomers (CABEs) used in Dr. Ameer s Lab. (a) NO treatment after thermo-cross-Unking (was shown to release NO for 3 days in vitro) [43-45] (b) in situ miscible diazeniumdiolated NO donors blended photo-cross-linked PDC. (was shown to release NO for more than 2 weeks in vitro) [41]. 

Since the creation of the first and initial citrate-based biodegradable elastomers (CABEs), poly(diol citrate) by Yang et al. in 2004, benefited from the facile and cost-effective synthesis process, available choices of diol comonomers (from small diol molecules to macrodiols, from hydrophobic diols to hydrophilic ones, and from saturated diols to unsam-rated diols), and the multifunctionality of citric add, CABEs have stood out and become an intensively studied and used biomaterial among the family of biodegradable polymers. 

Y. Zhang, R.T. Tran, l.S. Qattan, Y.-T. Tsai, L.P. Tang, C. Liu, J. Yang, Fluorescent imaging enabled urethane-doped citrate-based biodegradable elastomers. Biomaterials 34 (2013) 4048—4056. 

Polyester is a group of polymers that contain the ester functional group in their chain. Esters are chemical compounds derived from a carboxyUc acid and a hydroxyl compound, nsnally an alcohol. Most esters are considered biocompatible since they are endogenous to the human metaboUsm and able to break down to natural metabohc products by simple hydrolysis. Elastomers composed of aliphatic polyester chains cross-linked with each other by ester bonds, snch as poly(diol citrates) and poly(glyc-erol sebacate) (PGS), have received mnch attention because they are soft, elastic, and biocompatible [26,27]. Yang et al. synthesized the first citrate-based biodegradable elastomer (CABE), poly(diol citrates), in 2004 nsing a convenient and cost-effective polycondensation reaction [26,28]. 

Figure 4.6 (a) Synthesis of functional POC prepolymers POC-N3 and POC-Al (b) cartoon illustration of a new class of citrate-based biodegradable clickable elastomers (CABEs) with greatly improved mechanical strength and easily clickable surface for biofunctionalization (c) mechanical properties of cBPLP-Ser, cBPLP-Ser-N3, cBPLP-Ser-Al, and cBPLP-click (cBPLP-Ser-N3, Al) polymers (d) mechanical properties of CUPE, CUPE-N3, CUPE-Al, and CUPE-cUck (CUPE-N3, Al) polymers. The polymers used in (c) and (d) were cross-linked at 100 °C for 3 days. 

Figure 4.6 (a) Synthesis of functional POC prepolymers POC-N3 and POC-Al (b) cartoon illustration of a new class of citrate-based biodegradable clickable elastomers (CABEs) with greatly improved mechanical strength and easily clickable surface for biofunctionalization ... 

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