Haloperidol Citalopram

In most cases, SSRIs are the first choice for drugs to combat OCD. Clomipramine, fluvoxamine, fluoxetine, paroxetine, sertraline, and citalopram are all SSRIs that have been proven effective in reducing OCD symptoms. However, in about 40 to 60% of patients, these drugs do not completely alleviate all the symptoms. When this is the case, a second type of drug called a neuroleptic is often added. Neuroleptic drugs, such as haloperidol, clozapine, risperidone, and chlorpromazine... 

Ajmaline, alprenolol, amiflamine, amphetamine, aprindine, captopril, chlorpheniramine, cinnarizine, citalopram, clomipramine, clozapine, codeine, desipramine, dolasteron, encainide, flecainide, fluoxetine, fluphenazine, haloperidol, hydrocordone, imipramine, loratidine, methoxyphenamine, 3,4-methylenedioxymethamphetamine, metoprolol, mexiletine, (S)- and (i )-mianserin, nifedipine, olanzapine, omeprazole, oxycodone, perhexiline, phenformin, propaphenone, propranolol, remoxipride, ritonavir, saquinavir, selegiline, tamsulosin, timolol, tomoxetine, tramadol, trifluperidol, zolpidem... 

Bonomo V, Fogliani AM Citalopram and haloperidol for psychotic depression. Am. 1 Psychiatry... 

Citalopram does not interfere with the metabolism of APDs. At a dose of 40 mg/day, citalopram caused no significant changes in plasma concentrations of chlorpromazine, clozapine, haloperidol, perphenazine, thioridazine, or zuclopenthixol. Anecdotal data suggest that citalopram may increase the serum levels of levomepromazine. 

When a man taking citalopram 60 mg daily additionally took unknown amounts of ecstasy he became aggressive, agitated, severely grandiose, restless and performed compulsive movements in a peculiar and joyless dance-like marmer. He lacked normal movement control and said he could see little bugs. He was treated with haloperidol and chlordiazepoxide, and improved within 2 days of replacing the citalopram with promazine. ... 

Citalopram. A study in schizophrenic patients found that over a 12-week period the serum levels of haloperidol were not signifieantly altered by eit-alopram 40 mg daily. ... 

On the whole significant interactions between the antipsychotics and SSRIs appear rare (although see thioridazine, below). The combination can be useful and so the isolated cases of extrapyramidal adverse effects should not prevent concurrent use. However, if extrapyramidal effects become troublesome bear this interaction in mind as a possible cause. The significance of the rise in haloperidol levels caused by fluoxetine and fluvoxamine is unclear, be aware that haloperidol adverse effects may be increased in some patients and consider reducing the haloperidol dose if problems occur. The rise in perphenazine levels caused by paroxetine seems to result in a greater number of more serious adverse effects and so consideration should be given to reducing the dose of perphenazine if paroxetine is started. Citalopram may be a suitable alternative as it does not appear to affect perphenazine levels. 

Amperozide, amphetamine, methamphetamine, bambuterol, antidepressants (paroxetine, fluvoxamine, mianserin, and citalopram), anabolic steroids (glucuronides) promethazine, methadone, haloperidol, ibuprofen, naproxen, ketoprofen, propofol, ropivacaine Pb(ll), Mn(ll)... 

Noninterfering amitriptyline, bupropion, citalopram, clomipramine, clozapine, dox-epin, haloperidol, 2-hydroxydesipramine, 2-hydroxyimipramine, imipramine, loxapine, moclobemide, olanzapine, risperidone... 

Thieme, D. Sachs, H. Improved screening capabilities in forensic toxicology by application of liquid chromatography-tandem mass spectrometry, Anal.ChimActa, 2003, 492, 171-186. [hair LC-MS alprazolam dothiepin piritramide cocaine lorazepam lormetazepam clonazepam flimitrazepam bromazepam midazolam flurazepam nitrazepam temazepam medazepam nordazepam diazepam methylclonazepam triazolam oxazepam haloperidol benperidol sulpiride amisulpride mirtazapine citalopram olanzapine paroxetine fluoxetine sertraline zopiclone zolpidem risperidone quetiapine fentanyl pipamperone meperidine buprenorphine propoxyphene pentazocine phenazocine EDDP ... 

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