Ranitidine Cisplatin

Ito S, Weitzman S, Klein J, Greenbeig M, Lau R, Atanakovic G, Keren G. Lack of cisplatin-ranitidine kinetic interactiens m vivo study in children, and in vitro study usii d< renal bru border membrane vesicles. Life Sci (1998) 62, PL387-4 L392. 

The nephrotoxicity of dsplatin is reduced in humans [132], mice [133] and dogs [134] by co-admin-istration of probenecid, suggesting that cisplatin is transported by the PAH transport system. It has been proposed that platinum, hke other nephrotoxic metal ions such as mercury and potassium dichromate, are taken up by tubular cells as sulphydryl conjugate through a probenecid-sensitive pathway [133]. However, cisplatin might also be transported by the organic cation transport system, since quinidine, cimetidine and ranitidine inhibited its net secretion flux in the dog kidney [134]. 

Cimetidine and ranitidine probably do not have a clinically relevant effect on the renal clearance of cisplatin. 

Noninterfering amitriptyline, carbamazepine, carmustine, chlorpromazine, cimeti-dine, cisplatin, cyclophosphamide, dexamethasone, diazepam, digoxin, etoposide, furo-semide, haloperidol, ibuprofen, imipramine, indomethacin, methotrexate, phenobarbi-tal, phen3doin, propranolol, ranitidine, theophylline, triazolam, warfarin... 

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