Ciprofloxacin delivery

Wong JP, Yang H, Blasetti KL, Schnell G, Conley J, Schofield LN. Liposome delivery of ciprofloxacin against intracellular Francisella tularensis infection. J Controlled Release 2003 92 265-273. 

The experimental procedure below describes the uptake of ciprofloxacin into sphingomyelin (SPM)/Chol LUVs. Drug delivery vehicles prepared from SPM/Chol often exhibit greater efficacy than those prepared from DSPC/Chol (13). Included is a description of the Bligh-Dyer extraction procedure (78), which involves partitioning the lipid and water-soluble drug into organic solvent and aqueous layers, respectively. This is necessary because lipid interferes with the ciprofloxacin assay. 

J. Conley, H. Yang, T. Wilson, K. Blasetti, V. D. Ninno, G. Schnell, and J. P. Wong, Aerosol delivery of liposome-encapsulated ciprofloxacin aerosol characterization and efficacy against Francisella tularensis infection in mice, Antimicrob. Agents Chemother. 47 1288 (1997). 

Charoo, N. A., Kohli, K., Ali, A., and Anwer, A. (2003), Ophthalmic delivery of ciprofloxacin hydrochloride from different polymer formulations In vitro and in vivo studies, Drug Dev. Ind. Pharm., 29(2), 215-221. 

Balasubramaniam J, Pandit JK. Ion-activated in situ gelling systems for sustained release ophthalmic delivery of ciprofloxacin hydrochloride. Drug Delivery 2003 10(3) 185-191. 

An improvement of medical devices based on bacterial polymers by the encapsulation of different drugs, opens up the wide prospects in applications for these new devices with pharmacological activity in medicine. PHB polymer was used as a drug delivery matrix for sustaining the release of various drugs such as dipyridamole [DP], indomethacin and antibiotics (rifampicin, metronidazole, ciprofloxacin, levofloxacin), anti-inflammatory drugs (flurbiprofen, dexamethasone, prednisolone), and antitumor drugs (paclitaxel) [132]. 

Films of alginate and gelatin, cross-linked with Cs and containing ciprofloxacin hydrochloride as model drug in different concentrations, were obtained by a casting/solvent evaporation method. The film can lead to a successful application for localized dmg delivery in vivo or in vitro environments [135]. 

Fulzele S.V., Satturwar P.M., Dorle A.K., Novel biopolymers as implant matrix for the delivery of ciprofloxacin Biocompatibility, degradation, and in vitro antibiotic release, J. Pharm. Sci, 96(1), 2007, 132-144. 

Schierholz JM, Rump A, Pulverer G. New antiinfectious biomaterials. Ciprofloxacin containing polyurethanes as potential drug delivery systems to prevent foreign-body infections. Arzneimittelforschung Jannary 1997 47(l) 70-4. 

Antistaphylococcal antimicrobial substances (ciprofloxacin, gentamycin, fosfomycin, flucloxacillin) were incorporated into PUs by the solvent casting technique. Drug release rates, bacterial colonisation and morphological features were evaluated to predict and understand the antimicrobial activity of these delivery... 

Cellulose Based Drug Delivery Synthetic Nanoparticles, Microsphere, Tablet Excipients, Protein Based Drug Delivery, Spray Drying Acetaminophen, Cyclosporine A, Norfloxacin, Ofloxacin, Ciprofloxacin, Gatifloxacin, Levofloxacin, Protein delivery and purification... 

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