Nisoldipine Cimetidine

Drugs that may affect fluconazole include cimetidine, hydrochlorothiazide, and rifampin. Drugs that may be affected by fluconazole include alfentanil, benzodiazepines, buspirone, carbamazepine, cisapride, oral contraceptives, corticosteroids, cyclosporine, haloperidol, HMG-CoA reductase inhibitors, losartan, nisoldipine, phenytoin, protease inhibitors, rifabutin, sirolimus, sulfonylureas, tacrolimus, theophylline, tolterodine, tricyclic antidepressants, vinca alkaloids, warfarin, zidovudine, and zolpidem. 

Cimetidine also increases plasma concentrations of nitrendipine and nisoldipine (182,193). 

Clinically important, potentially hazardous interactions with amlodipine, bepridil, cimetidine, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil... 

The plasma levels of diltiazem, isradipine and nifedipine are increased by cimetidine and it may possibly be necessary to reduce the dosages of these calcium-channel blockers. High doses of cimetidine may increase the bioavailability of lercanidipine. Although studies surest no important interactions occur between nicardipine or nisoldipine and cimetidine, the manufacturers advise caution. Plasma felodipine, lacidipine, nimodipine, and... 

A study in 8 healthy subjects found that taking cimetidine 1 g in divided doses on the day before the study and then three 200 mg doses every 4 hours on the study day, increased the bioavailability of a single 10-mg dose of nisoldipine by about 50%, but the haemodynamic effects of the nisoldipine were unaltered7 Ranitidine does not interact with nisol-dipine. ... 

Ranitidine does not interact significantly with diltiazem, nimodipine, nisoldipine or nifedipine, and is possibly a non-interacting alternative for cimetidine with other calcium-channel blockers. Note that the nitrendipine AUC was increased by 50% and 89% by ranitidine, although this was not considered clinically relevant. 

VanHartenJ,vanBrummelenP,LodewijksMTM,DanhofM,BreimerDD Hiarmacckmet-ics and hemodynam ic effects of nisoldipine and its interaction with cimetidine. Clin Phama-colTher( 9ZZ) 43, 332-41... 

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