Moclobemide Cimetidine

Cimetidine Pilocarpine 3-Isopropenyl-3- Montelukast" Capecitabine Moclobemide"... 

Tyramine-rich foods, sympathomimetics, dextromethorphan, anorectics, and other antidepressants should be avoided when treating with moclobemide. It also interacts with opioid analgesics, serotonin agonists, NSAIDs, levodopa, and cimetidine.140,141... 

M.P. Schoerlin, et al., Cimetidine alters the disposition kinetics of the monoamine oxidase inhibitors moclobemide. Clin. Pharmacol. Then 49 32-38, 1991. 

CIMETIDINE MAOIs - MOCLOBEMIDE t plasma concentrations of modobemide (by up to 40%) Due to cimetidine inhibiting metabolism i dose of modobemide to one-half to one-third of original and then alter as required... 

Clinically important, potentially hazardous interactions with cimetidine, dihydroergotamine, ergot, fluoxetine, fluvoxamine, isocarboxazid, MAO inhibitors, methysergide, moclobemide, naratriptan, oral contraceptives, phenelzine, rizatriptan, sertraline, sibutramine, St John s wort, sumatriptan, tranylcypromine... 

Also analyzed acebutolol, acepromazine, acetaminophen, acetazolamide, acetophenazine, albuterol, amitriptyline, amobarbital, amoxapine, antipsrrine, atenolol, atropine, azata-dine, baclofen, benzocaine, bromocriptine, brompheniramine, brotizolam, bupivacaine, buspirone, butabarbital, butalbital, caffeine, carbamazepine, cetirizine, chlorqyclizine, chlordiazepoxide, chlormezanone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, chlorprothixene, chlorthalidone, chlorzoxazone, cimetidine, cisapride, clomipramine, clonazepam, clonidine, clozapine, cocaine, codeine, colchicine, qyclizine, (yclo-benzaprine, dantrolene, desipramine, diazepam, diclofenac, diflunisal, diltiazem, diphenhydramine, diphenidol, dipheno late, dipyridamole, disopyramide, dobutamine, doxapram, doxepin, droperidol, encainide, ethidium bromide, ethopropazine, fenoprofen, fentanyl, flavoxate, fluoxetine, fluphenazine, flurazepam, flurbiprofen, fluvoxamine, fii-rosemide, glutethimide, glyburide, guaifenesin, haloperidol, homatropine, hydralazine, hydrochlorothiazide, hydrocodone, hydromorphone, hydro g chloroquine, hydroxyzine, ibuprofen, imipramine, indomethacin, ketoconazole, ketoprofen, ketorolac, labetalol, le-vorphanol, lidocaine, loratadine, lorazepam, lovastatin, loxapine, mazindol, mefenamic acid, meperidine, mephenytoin, mepivacaine, mesoridazine, metaproterenol, methadone, methdilazine, methocarbamol, methotrexate, methotrimeprazine, methoxamine, methyl-dopa, methylphenidate, metoclopramide, metolazone, metoprolol, metronidazole, midazolam, moclobemide, morphine, nadolol, nalbuphine, naloxone, naphazoline, naproxen, nifedipine, nizatidine, norepinephrine, nortriptyline, oxazepam, oxycodone, oxymetazo-line, paroxetine, pemoline, pentazocine, pentobarbital, pentoxifylline, perphenazine, pheniramine, phenobarbital, phenol, phenolphthalein, phentolamine, phenylbutazone, phenyltoloxamine, phenytoin, pimozide, pindolol, piroxicam, pramoxine, prazepam, prazosin, probenecid, procainamide, procaine, prochlorperazine, procyclidine, promazine, promethazine, propafenone, propantheline, propiomazine, propofol, propranolol, protriptyline, quazepam, quinidine, quinine, racemethorphan, ranitidine, remoxipride, risperidone, salicylic acid, scopolamine, secobarbital, sertraline, sotalol, spironolactone, sulfinpyrazone, sulindac, temazepam, terbutaline, terfenadine, tetracaine, theophylline, thiethyl-perazine, thiopental, thioridazine, thiothixene, timolol, tocainide, tolbutamide, tolmetin, trazodone, triamterene, triazolam, trifluoperazine, triflupromazine, trimeprazine, trimethoprim, trimipramine, verapamil, warfarin, xylometazoline, yohimbine, zopiclone... 

Cimetidine increases the plasma levels of moclobemide. Mo-ciobemide dosage reductions are recommended. 

After taking cimetidine 200 mg five times daily for 2 weeks the maximum plasma levels of a single 100-mg dose of moclobemide in 8 healthy subjects was increased by 39% and the clearance was reduced by 52%. The probable reason is that the cimetidine (a well-recognised enzyme inhibitor) reduces the first-pass metabolism of the moclobemide. 

It has been recommended that if moclobemide is added to treatment with cimetidine it should be started at the lowest therapeutic dose, and titrated as required. If cimetidine is added to treatment with moclobemide, the dosage of the moclobemide should initially be reduced by 50% and later adjusted as neeessary. ... 

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