Chronotopic® system

Sangalli, M.E. Busetti, C. Maroni, A. Zema, L. Olgiati, V. Giordano, F. Gazzaniga, A. Chronotopic system for colon specific delivery pharmacokinetic and scintigraphic evaluation. Proc. Int. Symp. Control. Rel. Bioact. Mater. 1998, 25, 858-859. 

The Chronotopic system (Fig. 3) consisted of a core tablet containing the drug and a HPMC layer, optionally coated with an outer enteric coating. The lag time prior to drug release was controlled by... 

Drug delivery induced by swelling may be achieved with swellable polymer layers based on cellulose ethers or acrylates, where with the latter pH-dependent swelling behaviour is feasible [92]. Examples are the oral Chronotopic delivery system [93], the Tune-controlled Explosion ystem (TES) [94,95] and the TIME-CLOCK -System [96-98] (Figure 6.4). 

In the frame of the Theory of Relativity (Einstein) not only energy and mass are transmutable, but even space and time. Therefore the Chronotope shows 4 dimensions. Energy can be organized as matter or information, depending on different codifications of the chronotope. When energy is transformed in matter it assumes 3 spatial dimensions (x, y, z) plus one temporal dimension (t) while, if energy is transformed in information it assumes 2 spatial dimensions (e.g. plane wave) and 2 temporal dimensions (ti, t2). We have to underline these concepts, because the development of neg-entropy is needed in the evolution of natural systems, like landscapes and vegetation ones. 

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