Chronic rejection risk factors

Almond PS, Matas A, Gillingham K, Dunn DL, Payne WD, Gores P, Gruessner R, Najarian JS. Risk factors for chronic rejection in renal allograft recipients.Transplantation 1993 55 752-756. 

Matas, A. Chronic rejection in renal transplants—risk factors and correlates. Clin. Transplant. 1994, 8, 332-335. 

Cardiovascular disease is a leading cause of morbidity and mortality in transplant patients. Preexisting cardiovascular disease, which is common in end-stage organ failure, is not reversed with transplantation. Additionally, hypertension, hyperlipidemia, and diabetes are common complications in transplant recipients and are independent risk factors that contribute significantly to cardiovascular disease. Chronic rejection has been linked to hypertension and hyperlipidemia. ... 

Verleden GM, Egan J, Israel-Biet D, et al. Chronic lung allograft rejection prevalence, pathology, risk factors and pathophysiology. Eur Respir Mon 2004 29 1-18. 

Although acute rejection is rarely a cause of early mortality, it is the most important predictor of long-term survival (35). Most patients experience at least one episode of acrtte rejection during the first few weeks after transplant (7). Frequency and severity of rejection have been repeatedly identified as principal risk factors for chronic rejection or the development of bronchiolitis obliterans (36,37). 

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