Chronic active hepatitis nitrofurantoin

Intrahepatic cholestasis and hepatitis similar to that seen in chronic active hepatitis can rarely occur fatalities have been reported. Nitrofurantoin can interfere with immature red blood cell enzyme systems found in babies less than 1 month of age and in nursing infants. This leads to cellular damage and anemia. Nitro-... 

Hepatitis - chronic active Methyldopa, nitrofurantoin, isoniazid... 

The FDA warns that rare and sometimes fatal hepatic reactions to nitrofurantoin may occur and that the onset of chronic active hepatitis maybe insidious, Patients should therefore be monitored periodically using LFTs. The development of hepatitis warrants permanent discontinuation. 

Chronic active hepatitis may develop with prolonged use of methyldopa, isoniazid, dantrolene and nitrofurantoin. 

Amit G, Cohen P, Ackerman Z. Nitrofurantoin-induced chronic active hepatitis. Isr Med Assoc J 2002 4(3) 184-6. 

Black M, Rabin L, Schatz N. Nitrofurantoin-induced chronic active hepatitis. Ann Intern Med 1980 92(l) 62-4. 

Fagrell B, Strandberg 1, Wengle B. A nitrofurantoin-induced disorder simulating chronic active hepatitis. A case report. Acta Med Scand 1976 199(3) 237-9. 

Sharp JR, Ishak KG, Zimmerman HJ. Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin. Ann Intern Med 1980 92(1) 14-19. 

Hatoff et al. (1979) report a case of chronic active hepatitis in a HLA B 8-positive 27-year-old female patient after nitrofurantoin (Nole 1981). Agranulocytoses after nitrofurantoin have also been described (Palva und Lehmola 1973). In 12 of 20 patients antinucleic antibodies were seen, gammaglobulin was increased, and antibodies against smooth muscle appeared. All patients were negative to HBsAg. 

Eosinophilia was not observed. In one patient pulmonary fibrosis was seen, in another pulmonary infiltrates. In one patient with chronic active hepatitis a specific lymphocytic transformation was observed within 3 months after the beginning of therapy with nitrofurantoin, in another patient the authors observed immune complexes of polyclonal IgG antibodies and autologous albumin. Some patients, all women, had HLA B 8. 

Hatoff DE, Cohen M, Schweigert BF, Talbert WM (1979) Nitrofurantoin another cause of drug-induced chronic active hepatitis A report of a patient with HLA-B8 antigen. Am J Med 67 117... 

Shah V, Joshi M (1980) Alleviation of isoniazid (INH) induced malformations in chick embryos by amino acids. Indian J Exp Biol 18 1097 Sharma GS, Gupta PK, Jain NK, Shanker A, Nanawati V (1979) Toxic psychosis to isoniazid and ethionamide in a patient with pulmonary tuberculosis. Tubercle 60 171 Sharp JR, Ishak KG, Zimmermann HJ (1980) Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin. Ann Intern Med 92 14 Shaw D, Jacobs R (1970) Simultaneous occurrence of toxic hepatitis and Stevens-Johnson syndrome following therapy with sulfisoxazole and sulfamethoxazole. Johns Hopkins Med J 126 130... 

Strandberg I, Wengle B, Fagrell B (1974) Chronic interstitial pneumonitis with fibrosis during long-term treatment with nitrofurantoia Acta Med Scand 196 483 Stromberg A, Wengle B (1976) Chronic active hepatitis induced by nitrofurantoin. Br Med J 11 174... 

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