Chromium oxide, with acetic acid

Cyclodecanedione has also been prepared by oxidation of sebacoin with chromium trioxide in acetic acid, - Cupric acetate in acetic acid has been used for oxidation of an a-hydroxyketone by Ruggli and Zeller. ... 

A very violent detonation occurred when a mixture of chromium trioxide and acetic acid was heated (this mixture is used as an oxidant). The investigation showed that this accident was caused by liquid acid being in contact with oxide particles. These particles glowed and ignited the air/acid vapour mixture, which caused the apparatus to detonate. 

Oxidation with chromium trioxide in acetic acid cleaved the indole ring to produce intermediate 23 which cyclodehydrated to give prazepam (24). 

This oxidation has been used to determine the anomeric nature of sugar residues in oligosaccharides.153 The oligosaccharide is reduced to the alditol, this is acetylated, and the ester is treated with chromium trioxide in acetic acid in the presence of an internal standard. From the sugar analysis of the product, the residues that have survived (and, consequendy, are a-D-linked) may be identified. The... 

Oxidation with chromium trioxide in acetic acid,33 chromium trioxide in acetic anhydride-acetic acid,31 3-chloroperbenzoic acid in methylene chloride65 or benzene,74 or peracetic acid in acetic acid74 gave rise to isatoic anhydrides (64). 

S. J. Angyal and K. James, Oxidation of carbohydrates with chromium trioxide in acetic acid. I. Glycosides, Aust. J. Chem., 23 (1970) 1209-1221 Oxidation of carbohydrates with... 

I. Hoffman, B. Lindberg, and S. Svensson, Determination of the anomeric configuration of sugar residues in acetylated oligo- and poly-saccharides by oxidation with chromium trioxide in acetic acid, Acta Chem. Scand., 26 (1972) 661-666. 

The mixture 258 was converted to the unstable benzenesulfonyl aziridine 259 by treatment with an excess of benzenesulfonyl azide in benzene. Ace-tolysis of 259 with acetic acid and sodium acetate at room temperature for several days afforded the crystalline mixture of diastereoisomers represented by the formula 260. The aziridine rearrangement was regiospecific and 260 was the only product detected during this rearrangement. Lithium aluminium hydride reduction of 260 followed by acetylation yielded the mixture 261 in 85% yield. Selective hydrolysis of 261 afforded 262 in quantitative yield. The diastereoisomeric mixture 262 was converted into the diols 263 by hydrogenolysis. The diol mixture was oxidized with chromium trioxide... 

Lithium aluminium hydride reduction of lucidusculine (35) afforded napelline (34) in quantitative yield. Napelline was hydrogenated with platinum oxide in acetic acid to afford dihydronapelline (286). Treatment of 286 with mercuric acetate in aqueous acetic acid followed by oxidation with chromium trioxide in pyridine afforded 287 in 16.5% yield. Ketalization of 287 yielded 285 in a yield of 71%. On refluxing 285 with methanolic base, a 4 6 equilibrium mixture of 285 and 288 was obtained. These compounds... 

In order to obtain the trans-fused octalin, the cis-fused octaline 423 was oxidized with chromium trioxide in acetic acid to yield the ketone 424. The latter was treated with bromine in acetic acid to produce the a-bromoketone 425 in a yield of 98%. Dehydrobromination of 425 with. /V-phenylbenz-amidine afforded the a/i-unsaturated ketone 426 in 90-95% yield. The... 

The A5 double bond in steroids, which is seldom hydrogenated over platinum oxide in neutral solvent or Raney Ni, has been hydrogenated selectively in the presence of the oxo groups at C3, C17, or C20 over Pd-C in alcohol (eqs 3.50209 and 3.51210) or platinum oxide in acetic acid (eqs 3.52211 and 3.53212). In the latter cases using platinum oxide in acetic acid, however, some formation of 5(5 compounds took place. Small amounts of overhydrogenation products were oxidized to the ketones with chromium trioxide. 

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