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Cholinesterase inhibitors specific agent

Organophosphorus nerve agents are potent cholinesterase inhibitors, specifically acetylcholinesterase (AChE), the... [Pg.20]

Cholinesterase inhibitors are a very important class of compounds related to cholinomimetics. Besides their therapeutic importance, a few of them are used as pesticides in agriculture, and the most toxic are used as chemical poisoning agents. Use of these substances is based on changes that take place after inactivation of cholinesterase or pseudocholinesterase (a less specific enzyme), i.e. effects observed as a result of acetylcholine buildup in neuro-effector compounds. Cholinesterase inhibitors are classified both by their chemical structure as well as by the type of their chemical reaction with the enzyme, which determines their temporary action. [Pg.186]

Quaternary phosphonium compounds were also found to be reversible inhibitors of cholinesterases of different animals and showed species-specificity of action depending on their inhibitor stmcture. The use of phosphonium salt-containing materials as antimicrobial agents was also reported. For example, new 2,6-di-tert-butylphenol derivatives possessing simultaneously phosphonium and phosphonate fragments were reported... [Pg.92]

See other pages where Cholinesterase inhibitors specific agent is mentioned: [Pg.115]    [Pg.51]    [Pg.459]    [Pg.479]    [Pg.486]    [Pg.667]    [Pg.181]    [Pg.67]    [Pg.977]    [Pg.220]    [Pg.1163]    [Pg.175]    [Pg.426]    [Pg.184]    [Pg.207]    [Pg.300]    [Pg.299]    [Pg.327]    [Pg.186]    [Pg.23]    [Pg.137]    [Pg.333]    [Pg.979]    [Pg.23]    [Pg.299]    [Pg.155]    [Pg.767]   


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