Cholesterol sulfate sodium salt

Of the activated alcohols described in Section 1.1.2.S.1, alkyl sulfonates ate convenient alkylating re-agents because they can be readily prepared and handled. The correct choice of sulfate-alcoholate combination is often crucial for successful ether synthesis. Thus, for the preparation of cholesteryl ethers from the tosyl derivative of cholesterol and alkoxides, the reaction must be carried out at 110 °C for 2.S h in a sealed tube. Alternatively, the sodium salt of cholesterol can be reacted with an alkyl mesylate at 80 °C for 1 h in DMF to give the corresponding ether in 62-68% yield. ... 

Cholesterol sulfate occurs in bovine adrenal glands (Drayer et ai, 1964). This fact raises the possibility that the conjugate may represent an active form of cholesterol in metabolic processes other than those concerned with steroid hormone biosynthesis. Isolation of the sodium and pyridinium salts of cholesterol sulfate and recording of their infrared spectra led to the identification of these compounds. 

Commonly, lipids like glycerides (mono-, di-, or tri-), waxes (e.g., camauba wax, beeswax, cetyl alcohol, emulsilying wax, cholesterol, cholesterol butyrate, etc.), and vegetable oils are nsed as carriers to dissolve/disperse the drug molecules. The surfactants (e.g., polysorbates, sodium dodecyl sulfate, castor oil, bile salts, etc.) and cosurfactants (e.g., alcohols, polyethylene glycol, cranophor, poloxamer, etc.) are used to emulsify the molten lipid mixture in aqneons media The SLNs can then be lyophilized with excipients to obtain the dried powder. The list of excipients and formnlations of the marketed products is found in Mehnert and Mader and Pardeike et... 

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