Cholesterol-free diet, fecal

Fecal Steroid Excretion of Rats at 4th Day Refeeding Period on Cholesterol-Free Diet... 

Some investigators have examined the effect of protein on fecal steroid excretion. Sautier et al. (1979) demonstrated that rats fed cholesterol-free, semipurified diets containing soy protein isolate had a greater fecal dry weight and excretion of neutral steroids than animals fed a diet containing casein. Nevertheless, plasma cholesterol levels remained unchanged in spite of the increased fecal excretion of steroids. 

Sesame oil affects cholesterol mobility in the human organism. To study the potential activity of other kinds of compounds, Hirose et al. [222] analysed the effects of sesamin, a lignan present in the oil, on various aspects of cholesterol metabolism, and they observed that a diet with sesamin reduced the concentration of serum and liver cholesterol except in the group free of cholesterol. Sesamin decreased lymphatic absorption of cholesterol and increased the fecal excretion of the neutral but not the acidic form. At the liver level, there was a significant reduction in the activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase, but the activity of hepatic cholesterol 7a-hydroxylase and alcohol dehydrogenase were not affected. Microscopic histological examination did... 

The efficacy of capsaicin as a hypocholesterolemic agent has also been investigated in animals fed cholesterol in their diets. Sambaiah and Satyanarayana [104] have reported that the serum cholesterol levels in rats on a 1 % cholesterol -i- 5 % red pepper diet were lower than those not fed with red pepper. Liver cholesterol was lower in the red pepper- as well as capsaicin (an equivalent level of 15 mg%)-fed groups. Fecal excretion of free cholesterol and of bUe acids was enhanced in animals fed the spice and capsaicin. The anti-hypercholesterolemic efficacy of dietary capsaicin has been evidenced in rats fed an atherogenic high-cholesterol diet, and such an influence also resulted in countering of the changes in membrane lipid profile in the erythrocytes [105]. In streptozotocin-induced diabetic situation however, dietary capsaicin did not show any beneficial hypolipidemic property [106]. 

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