Cholesterol dose-response relationship

FIGURE 17.4 Results of a study that established the dose-response relationship betwreen sinavastatin dose and percent reduction in serum cholesterol levels in patients wdth heterozygous familial hypercholesterolemia. 

In a recent study, a dose-response relationship was found between THC and the transition temperature shift for lecithins [113]. The cholesterol content was again found to influence this effect. 

Epidemiological and Human Dosimettv Studies. Acute high-level exposure to zinc by inhalation resulted in respiratory irritation and metal fume fever (Blanc et al. 1991 Hjortso et al. 1988 Johnson and Stonehill 1961 Linn et al. 1981 Schenker et al. 1981 Sturgis et al. 1927). Welders are a subpopulation of workers who have a high potential for exposure to zinc oxide. Most of the available studies did not report exposure levels or used a small number of subjects. Studies that correlate occupational exposure to zinc with health effects would be useful. A number of human oral exposure studies have shown that excess levels of zinc can result in anemia, pancreatic damage, decreased serum HDL cholesterol levels, and immunotoxicity (Black et al. 1988 Chandra 1984 Hooper et al. 1980). There are insufficient data for establishing dose-response relationships. 

Figure 4 shows total plasma cholesterol after 3 months on the different diets. In the groups not fed dietary cholesterol pectin gave a slight but significant plasma cholesterol increase. As in Experiment 1, wheat bran also increased the total cholesterol and there seemed to be a dose-response relationship. 

Due to the dose-response relationship between saturated fat and plasma LDL cholesterol levels, the lOM recommends saturated fat consumption to be as low as possible, while maintaining the recommended 20 to 35% of total calories from fat. More specifically, adults with plasma LDL cholesterol concentrations below 130 mg/dl should consume less than 10% of calories from samrated fat, while adults with elevated LDL cholesterol (greater than or equal to 130 mg/dl) should consume less than 7% of their total calories from saturated fat. As previously mentioned, not all samrated fat raises plasma LDL cholesterol levels, exemplified by stearic acid (18 0) exerting a nentral or hypocholesterolemic effect. Despite strong evidence that individual fatty adds have independent effects on plasma cholesterol levels, no recommendations for individnal fatty acid consumption have been made. 

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