Chlorohydrins tetramethylene chlorohydrin

Note 2) and weighs 95-100 g. A small amount (5-10 g.) of high-boiling material remains. The crude product on refractionation yields 93-98 g. (54-57 per cent of the theoretical amount) of pure tetramethylene chlorohydrin boiling over a one-degree interval, 8r-82°/i4 mm. or 70-71 /7 mm. (Notes 3 and 4). 

It has been reported that tetramethylene chlorohydrin undergoes loss of hydrogen chloride when distilled at pressures appreciably above 15 mm. If an oil pump is used for the distillation of the main fraction, it should be protected from hydrogen chloride by means of soda-lime towers. 

Tetramethylene chlorohydrin may be converted to the chlorobromide in excellent yields by the action of phosphorus tribromide. ... 

Tetramethylene chlorohydrin was first prepared in a pure state by the action of thionyl chloride on tetramethylene glycol in the presence of pyridine. The method given here has been published recently... 

SYNS 4-CHLORBUTAN-l-OL (GERMAN) 4-CHLORO-l-BUTANE-OL 4-CHLOROBUTANOL TETRAMETHYLENE CHLOROHYDRIN... 

TETRAMETHYLENE CHLOROHYDRIN see CEU500 TETRAMETHYLENE CYANIDE see AER250 TETRAMETHYLENEDIAMINE see BOSOOO... 

The cleavage of tetrahydrofuran and its alkylated derivatives with halogen acids is an excellent method for the preparation of, A-dihalo-alkanes.The reaction of tetrahydrofuran with the less-reactive hydrogen chloride stops at the chlorohydrin stage, whereas the reaction in the presence of zinc chloride catalyst leads to the formation of the dichloride. The crude reaction mixture containing the intermediate chlorohydrin may be treated directly with phosphorus tribromide, yielding tetramethylene chlorobromide. The preparation of dibromides can be accomplished easily with hydrogen bromide or phosphorus and bromine and diiodides, by the action of potassium iodide and orthophosphoric acid. ... 

Tetramethylene chlorohydrin caused tumors in lungs in test animals. Its carcinogenicity, however, is not yet fnlly established. 

Tetramethylene chlorohydrin is bnmed in a chemical incinerator equipped with an afterburner and scrubber. 

Tetramethylene chlorohydrin can be analyzed by GC-FID using a suitable column. 

Tetramethylene chlorohydrin in H2O is converted into THF about 10 times faster compared to ethylene chlorohydrin conversion into ethylene oxide (Scheme 2.43). 

The iminoether 9 was prepared according to the procedure of Nohira et al. (9) in which tetramethylene chlorohydrin, potassium cyanide, glycerol and water were heated at 100-110 C to give the cyanohydrin. The hydrochloride salt of the imino ether was formed by passing HCl gas into the ether solution of... 

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