Chloroammineplatinum

Table I. Rate Constants for the Hydrolysis and Chloride Exchange of Chloroammineplatinum (II) Complexes ...

The rate constant for the formation of the cis, the number that should be in the table now is 5.6 x 10-5 sec.-1. The value of the rate constant for the formation of the trans isomer is 0.62 x 10-6 sec. "1. With the six rate constants for this particular system of the chloroammineplatinum(II) complexes I would like to indicate a correlation that can now be made. 

It was clear in the 1950s that there was a need for detailed kinetic studies of ligand substitution reactions of platinum(ii) complexes, and our laboratory was prepared to do this because it was engaged in such studies of octahedral substitution. However, only a brief account of our studies is given in this article. At about this time Martin and his students initiated their investigations of aquation reactions of chloroammineplatinum(ii) complexes. 

Correlations of Physico-Chemical and Biological Properties with in Vivo Biodistribution Data for Platinum-195 m -Labeled Chloroammineplatinum(II) Complexes... 

Figure 2. Schematic of the microscale syntheses of Pt-radiolabeled chloroammineplatinum(II) complexes. Reactions are carried out at ambient temperature unless specified otherwise. Yields relative to the Pt target are enclosed in parentheses. NHs and Pt are denoted by A and Pt,...

Table II. Tissue Distribution of Chloroammineplatinum(II) 344 Rat at 24- h Post-Injection i.v., tail Complexes in the vein) (A = NH3) Fischer (female) ...

Figure 8. Comparison of the order of chloroammineplatinum(ll) compound retention in ail tissues with rate fkj and equilibrium (K g) constants for aquation. Equilibrium and rate data (Ref. 16) are normalized relative to cis-[Pt(NHa)3Clt].

J. D. Hoeschele, T. A. Butler, and J. A. Roberts Correlations of Physico-Chemical and Biological Properties with In Vivo Biodistribution Data for Platinum-195m-Labelled Chloroammineplatinum(II) Complexes (Inorganic Chemistry in Biology and Medicine, ACS Symposium Series v. 140, Ed. A. E. Martell) p. 181. ACS, Washington (1980). 

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