Pt-radiolabeled chloroammineplatinum II complexes

At the microscale level, a key stratagem which greatly facilitates the synthesis of these complexes Is to accurately determine the specific activity of I95mp - after dissolution 

The central position of eis-[Pt(NH3)2Cl2] in this scheme emphasizes the importemce of this complex as the preferred starting material In the synthesis of three of the remaining chloro-aiimilneplatlnum(II) complexes. It is an Ideal starting material because the microscale synthesis has been optimized to a degree which permits synthesis of a pure compound In a 75% overall yield based on the Irradiated Pt metal target (17). 

The Pt-labeled complexes of the general structure, [PtAj,jCl2 (A=CH3NH2 and i-C3H7NH2), were synthesized using procedures Identical to that for [Pt(NH3)i,]Cl2, except that NH3 was replaced by the other amines. 

ACS Symposium Series American Chemical Society Washington, DC, 1980. 

Blodlstrlbutlon Studies. Normal female Fischer 344 rats, 

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Figure 2. Schematic of the microscale syntheses of Pt-radiolabeled chloroammineplatinum(II) complexes. Reactions are carried out at ambient temperature unless specified otherwise. Yields relative to the Pt target are enclosed in parentheses. NHs and Pt are denoted by A and Pt,...

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