1- Chloro-2,2,2-trifluoroethyl

The observation by Yarovenko and Raksha " in 1960 that diethyl (2-chloro-1,1,2-trifluoroethyl) amine (hereafter called fluoroamine ) could replace hydroxyl groups by fluorine was first applied in the steroid field byAyer and Knox and co-workers. These workers found that a methylene... 

Figure 7.1.9 The molecular structure of enflurane (enthrane or 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether).

A comparison of various fluorinating agents in the preparation of fluoride 13, i.e. (2-chloro-1,1,2-trifluoroethyl)diethylamine and diethylaminosulfur trifluoride (R = H), tetrafluoro(phen-yl)-A5-phosphane (R = TMS), and potassium fluoride (R = Ts), has shown that the highest stereoselectivity is achieved with potassium fluoride and (2-chloro-l,1,2-trifluoroethyl)-diethylamine.19 The fluorination with tctrafluoro(phenyl)-7.5-phosphane proceeds, at least in part, via a carbocation and with a relatively low enantioselectivity.15... 

CHLORO-l,l,l-TRIFLUOROETHANE see pY175 2-CHLORO-1,1,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER see EAT900 CHLOROTRIFLUOROETHYLENE see CLQ750... 

AT-Chloroamines, 325, 395-398 Chloroiridic acid, 146 Chloromethylation, 184 Chloronium ion, 92 AT-Chlorosuccinimide, 184 2 -Chloro-1,1,2-trifluoroethyl di-ethylamine, 47. 251, 268, 271 Cholesterol, substitution reactions, 47... 

Synonyms/Trade Names 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether Ethrane ... 

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