4-benzyl-1-phenethyl

Hu, K., and M.E. Morris. 2004. Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRPl-mediated transport. J Pharm Sci 93 1901. 

Dialkyl Diethyl Dibutyl Diamyl Phenyl Benzyl Phenethyl... 

Ph.CH2.OMe, Ph.(CH2)2.0Me, Ph.(CH2)3.0Me (2-3, 3-4, 1-3), does not decrease steadily, but goes through a maximum. These two circumstances point to a specific -interaction in nitrations of the ethers with acetyl nitrate which is important with benzyl methyl ether, more important with methyl phenethyl ether, and not important with methyl phenpropyl ether. This interaction is the reaction with dinitrogen pentoxide already mentioned, and the variation in its importance is thought to be due to the different sizes of the rings formed in the transition states from the different ethers. 

Benzyl alcohol, [100-51 -6] C H CH20H (bp, 205.4°C at 101.3 kPa), produced by the hydrogenation of benzaldehyde is used in color photography as a parenteral solution preservative as a general solvent and as an intermediate in the manufacture of various benzoate esters for the soap, perfume, and flavor industries (see Benzyl alcohol and P-phenethyl alcohol). 

Benzyl alcohol (1) and P-phenethyl alcohol (2) (2-phenylethanol) are the simplest of the aromatic alcohols, and, as such, are chemically similar. Their physical properties are given in Table 1. 

Table 1. Physical Properties of Benzyl Alcohol and p-Phenethyl Alcohol...

Nearly all of the benzyl chloride [100-44-7], henzal chloride [98-87-3], and hen zotrichl oride /P< -(97-i manufactured is converted to other chemical intermediates or products by reactions involving the chlorine substituents of the side chain. Each of the compounds has a single primary use that consumes a large portion of the compound produced. Benzyl chloride is utilized in the manufacture of benzyl butyl phthalate, a vinyl resin plasticizer benzal chloride is hydrolyzed to benzaldehyde hen zotrichl oride is converted to benzoyl chloride. Benzyl chloride is also hydrolyzed to benzyl alcohol, which is used in the photographic industry, in perfumes (as esters), and in peptide synthesis by conversion to benzyl chloroformate [501-53-1] (see Benzyl ALCOHOL AND p-PHENETHYL ALCOHOL CARBONIC AND CARBONOCm ORIDIC ESTERS). 

A -Benzyl-A -methylephedrinium bromide [benzyl(2-hydroxy-l-methyl-2-phenethyl) dimethylammonium bromide] [58648-09-2] M 350.3, m 209-211 , 212-214 , [al -3.8 (c... 

In contrast, flash-vacuum pyrolysis (FVP)155 or spray-vacuum pyrolysis (SVP)154 of the homologous phenethyl azidoformates yield, in every instance except for the 4-cyano and 4-nitro-derivatives, the thermally stable [1,3]oxazino[3,4-a]azepines 9 accompanied by lesser amounts of the oxazolidinones 10, formed by nitrene insertion at the benzylic carbon center. 

In the reaction of 88 with /(-phenethyl bromide, l-phenethyl-3-phenylpropyl methyl sulfoxide and bis-3-phenylpropyl sulfoxide, besides 3-phenylpropyl methyl sulfoxide are obtained118. Sulfoxides, bearing a /1-hydrogen to the sulfmyl function, give olefins upon thermolysis. Utilizing this reaction, Trost and Bridges120 alkylated benzyl phenyl sulfoxide, 3,4-methylenedioxybenzyl phenyl sulfoxide, phenylthiomethyl phenyl sulfoxide, phenylsulfinylmethyl phenyl sulfoxide and cyanomethyl phenyl sulfoxide with alkyl, allyl and benzyl halides and subjected these sulfoxides to thermolysis, obtaining olefins in one-pot processes. 

Besides benzyl chloride, methyl- and/or chlorine-substituted benzyl chlorides, phenethyl chloride, etc. are also successfully employed to give 2 -diaralkylaminofluorans in excellent yield. However, aryl halides such as chlorobenzene and bromobenzene hardly enable the reaction, though aryl iodides such as iodobenzene give 2 -diarylaminofluorans in low yield. 

N-benzyl-N-phenethyl-N,N-dimethylammonium chloride loses predominantly benzyl when heated with thiophenoxide, giving stable N,N-dimethylphenethylamine (47) ... 

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