Chloro acetyl bromide

In a modern version of well-established Af-oxide chemistry, l,3-dimethyllumazine-5-oxide was converted into the corresponding 6-triflate using trifluoromethanesulfonic anhydride thereby opening the way to many reactions mentioned in Section 10.18.7.2 <1997PTR1> <2002H(57)1841>. Similar reactions with acetyl chloride and acetyl bromide afforded the corresponding 6-chloro- and 6-bromolumazines. 

When sodium chloride is fused with anhydrous chromium(II) chloride the product is NaCrCI5 regardless of the proportions of chlorides used.222 Other cations give tetra- or tri-chloro-chromates(II) as in Sections 35.3.7.3.ii and 35.3.7.3.vi above. The solvate [pyH]3[CrBr5]-2MeC02H has been isolated from the metal acetate and pyridine in a mixture of acetyl bromide and acetic acid, and there is considerable splitting of the spin-allowed d-d band in the reflectance spectrum of this complex,255 but no detailed investigations of pentahalochromates have been reported. 

Nitro-6-chloropyridazine 1-oxide reacts with nucleophiles with displacement of the 6-chlorine atom (even with acetyl bromide), except with sodium methoxide. Merer, the 3-nitro group is diplaced. Nucleophilic substitution with amines was investigated for various monoalkoxydihalo-or dialkoxyhalopyridazines. Normally, the chlorine atom is replaced, but in 3-chloro-4,6-dialkoxy- or 4-alkoxy-3,6-dichloropyridazines the alkoxy group may be replaced preferentially or concurrently. The 6-chlorine atom of methyl (3,6-dichloropyridazin-4-yl)-acetate was displaced by hydrazine or on hydrolysis. ... 

METHYL HYDRATE (67-56-1) CH O CH3OH Flammable liquid. Forms explosive mixture with air [explosion limits in air (vol %) 6.0 to 36.5 flash point 52 F/11 C autoignition temp 725°F/385°C 867°F/464°C " Fire Rating 3]. Violent reaction (possible fire and/or explosion) with strong oxidizers strong mineral acids (e.g., nitric, sulfuric, perchloric) acetyl bromide alkyl aluminum salts beryllium dihydride bromine, chromic acid l-chloro-3,3-difluoro-2-methoxycyclopropene, cyanuric chloride diethylzinc, isophthaloyl chloride potassium-ferf-butoxide phosphorus trioxide platinum-black catalyst (ignition) potassium sulfur diimide Raney-nickel catalysts 2,4,6-trichlorotriazine, triethylaluminum, 1,3,3 -trifluor o-2 -... 

MONOHYDROXYMETHANE (67-56-1) Forms explosive mixture with air (flash point 50°F/10°C). Violent reaction with strong oxidizers, acetyl bromide, alkyl aluminum salts, beryllium dihydride, bromine, chromic acid, l-chloro-3,3-difIuoro-2-methoxycyclopropene, cyanuric chloride, diethylzinc, isophthaloyl chloride, nitric acid, perchloric acid, potassium-tert-butoxide, potassium sulfur diimide, Raneynickel catalysts, 2,4,6-trichlorotriazine, triethy-laluminum, l,3,3-trifluoro-2-methoxycyclopropene. Incompatible with strong acids, strong caustics, alkalineearth and alkali metals, aliphatic amines, acetaldehyde, benzoyl peroxide,... 

Use of a large, lipophilic nitrogenous component results in a 1idocaine like, local anesthetic type cardiac anti-arrhythmic drug, lorcainide (20). Synthesis begins with the Schiff s base (1 ) derived by reaction of p-chloro-aniline and borohydride followed by acylation with phenyl acetyl chloride produces amide 1 . Selective hydrolysis with HBr followed by alkylation with isopropyl bromide completes the synthesis of lorcainide (20). ... 

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