Chloro acetamide

Glorius, F. Palladium-catalyzed Heck-type reaction of 2-chloro acetamides with olefins. Tetrahedron Lett. 2003, 44, 5751—5754. 

Raghavendra et al. have synthesized selenopheno[2,3-6]quinoline-2-carbox-amide (4) and phenyl(selenopheno[2,3-6]quinolin-2-yl)methanone (5) in good yields by treating 2-(hydroseleno)quinoline-3-carbaldehyde (3) with 2-chloro-acetamide and phenacyl bromide, under solvent-free MWI in one-pot reaction... 

Oxalyl chloride, reaction with a chloro-acetamide, 46,16... 

Hexachloroacetone, reaction with a variety of amines to form the corresponding ar,at,a-tri-chloro-acetamides, 40,104... 

The hydrolysis product 51 can alternatively be accessed directly from the reaction of the thiol derivative 48 with chloro acetamide. Other electrophiles for the reaction with the thiol derivative were also described which lead to functionalized tetrazole or 5-6 fused bicyclic ring systems. 

Similarly, in the so-called crab-like cyclisation reaction of an a-chloro-acetamide with secondary amines15 which takes place in the presence of sodium carbonate in acetonitrile (Scheme 1.10), the product diamide possesses three distinctive nitrogen sites. Such a reaction may be carried out under medium dilution, when yields of around 50% are common. If the reactants are added slowly using syringe pumps and the reaction is undertaken at high dilution, then the yield improves to 80%. 

SYNS CHLORACETAMID (GERMAN) CHLORO-ACETAMIDE (X-CHLOROACETAMIDE 2-CHLOROETHANAMIDE USAF DO-29... 

DIALLYLCHLOROACETAMIDE N,N-DIALLYL-CHLOROACETAMIDE N,N-DIALLYL-a-CHLORO-ACETAMIDE N,N-DIALLYL-2-CHLOROACETAMIDE... 

The incorporation of (2- C) acetate in the hexane extracted fatty acid fraction could also be inhibited through the chloro-acetamide herbicides tested, data not shown. 

Gibberellin biosynthesis is a proven target site for growth retardants such as chlormequat chloride (CCC), ancymidol, chlorphonium chloride, and daminozide. However, gibberellin biosynthesis has also been proposed as a target site for the members of the thiocarbamate and chloro-acetamide classes of herbicides (Figure 5.12). 

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