Oral contraceptives chlordiazepoxide

Oral contraceptives Increased free concentration of chlordiazepoxide and slightly decreased Cl decreased Cl and increased f1/2 of diazepam and alprazolam... 

Oral contraceptives Decreased Cl and increased t of diazepam and chlordiazepoxide decreased t of lorazepam and oxazepam... 

TABLE 5-4. Effect of oral contraceptives on chlordiazepoxide and diazepam ... 

Roberts RK, Desmond PV, Wilkinson GR, et al Disposition of chlordiazepoxide sex differences and effects of oral contraceptives. Clin Pharmacol Ther 25 826-831, 1979... 

Oral contraceptives alter the metabolism of some benzodiazepines that undergo oxidation (chlordiazepoxide, alprazolam, diazepam) or nitroreduction (nitrazepam) (334). Oral contraceptives inhibit enzyme activity and reduce the clearances of these drugs. There is nevertheless no evidence that these interactions are of clinical importance. For other benzodiazepines that undergo oxidative metabolism, such as bromazepam and clotiazepam, no change has ever been found in oral contraceptive users. 

In 7 healthy young women who had taken oral contraceptives for more than 6 months the protein binding of chlordiazepoxide was reduced and its volume of distribution increased (6). The clearance of chlordiazepoxide is also reportedly reduced by oral contraceptives (7). 

Mid-cycle spotting occurred in a large proportion of 72 women taking oral contraceptives and chlordiazepoxide however, there were no pregnancies (8). 

Antianxiety agents e.g., chlordiazepoxide, diazepam Diuretics e.g., hydrochlorothiazide Hormone therapies Oral contraceptives, hormone replacement therapy... 

Clinically important, potentially hazardous interactions with alprazolam, benzodiazepines, chlordiazepoxide, clonazepam, clorazepate, diazepam, dihydroergotamine, ergot, flurazepam, lorazepam, methysergide, midazolam, oral contraceptives, oxazepam, quazepam, temazepam, triazolam... 

Clinically important, potentially hazardous interactions with alfentanil, alfuzosin, alprazolam, amiodarone, amprenavir, aprepitant, astemizole, atazanavir, bepridil, buprenorphine, bupropion, carbamazepine, chlordiazepoxide, ciclesonide, clozapine, conivaptan, cyclosporine, cyproterone, dasatinib, diazepam, dihydroergotamine, ergot alkaloids, estazolam, eszopidone, etravirine, ezetimibe, fentanyl, fesoterodine, flecainide, flurazepam, fluticasone, halazepam, ivabradine, ixabepilone, ketoconazole, lapatinib, levothyroxine, meperidine, meptazinol, methysergide, midazolam, nifedipine, nilotinib, oral contraceptives, phenytoin, pimozide, piroxicam, propafenone, propoxyphene, quazepam, quinidine, ranolazine, rifabutin, rifampin, rifapentine, rimonabant, rivaroxaban, saquinavir, sildenafil, silodosin, simvastatin, solifenacin, St John s wort, tadalafil, temsirolimus, trabectedin, triazolam, vardenafil, voriconazole, zolpidem... 

Similar but less marked effects were found in other studies in women taking oral contraceptives given chlordiazepoxide, diazepam, alprazolam and to an even lesser extent with triazolam and nitrazepam. No clinically significant pharmacokinetic changes were seen with bromazepam, clotiazepam, midazolam (given orally intramuscularly or intravenously ) or zolpidem."... 

Oral contraceptives affect the metabolism of the benzodiazepines by the liver in different ways oxidative metabolism is reduced (alprazolam, chlordiazepoxide, diazepam, etc.), whereas metabolism by glucuronide... 

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