Chiro

C15H3i5N405 3.5 H20 0-(2,6-Diamino-2,3,4,6-tetradeoxy-6-C-methyI-a - d - en/thro-hexopyranosyl) - (1 — 4) - l - 3 - amino -1,3,6- trideoxy -1 -methoxy-6-(methylamino)-chiro-inositol, hydrate (fortimicin B, hydrate) (FORTBH)52... 

Reichardt, C. (1992). Solvatochromism, thermochromism, piezochromism, halochrom-ism, and chiro-solvatochromism of pyridinium IV-phenoxide betaine dyes. Chem. Soc. Rev. 21, 147-153... 

Another approach to CPL is the synthesis of conjugated polymers with intrinsic chiro-optical properties. A variety of polymers with CPPL have been synthesized so far. Most of them are based upon well-known conjugated polymers such as poly(thiophene)s [4,111], polyphenylene vinylene)s [123], poly(thienylene vinylene)s [124], ladder polymers [125], PPPs [126], polyphenylene ethynylene)s, [127] and poly(fluorenes) [128]. All of them have been modified with chiral side-chains, which induce the chiro-optical properties. 

Scheme 2.2 Graphical representations of the inner and outer phases of the chiro-RAM-TE support. G = grafting group (monoureido-monoisocyanate intermediate), obtained as previously described [61] (i) LiCl/dry DMSO, 80°C, 3 h. (ii) dry pyridine, 70°C, 12 h.

A special mention in the field of enantioselective HPLC separations must be made of chiro-optical detection systems, such as circular dichroism (CD) and optical rotation (OR), which can be also used to circumvent the low UV detectability of chromophore-lacking samples [40, 61]. While sensitivity of chiro-optical detection is not always sufficient to perform enantiomeric trace analysis, the stereochemical information contained in the bisignate spectropolarimetric response is useful in establishing elution order for those compounds not available as single enantiomers of known configuration. An example of application of different online detection systems (UV and CD at 254 nm) in the enantioselective separation of a racemic sulfoxide on a commercially available TAG CSP is reported in Figure 2.12, under NP conditions. 

An example of LC-MS separation of four racemic 3-blockers achieved on a TE CSPis reported in Figure 2.16. The chromatographic assay developed was applied in the direct HPLC injection of human plasma containing sotalol on a chiro-RAM-TE support [64] (Figure 2.17). 

Ciogli, A. et al., A new chiral and restricted access material containing teicoplanin as selector (chiro-RAM-TE) for the HPLC determination of chiral drugs in biological matrices, presented at 16th Int. Symp. on Chirality, New York, July 11-14, 2004, 62. 

Broza, M., Halpern, M., Teltsch, B., Porat, R., and Gasith, A. Shock chloramination potential treatment for Chiro-nomldae (Diptera) larvae nuisance abatement in water supply systems. J. Econ. Entomol, 91 (4) 834-840, 1998. 

There are two main points of interest. First, the extent of inversion varied over a wide range, and second, the high degree of inversion found for the aminodeoxy-scyiio- (46) and 3-amino-3-deoxy-chiro-inositol acetates was in marked contrast to the predominant retention of configuration observed in the deamination of simple, equatorial amines. 

Just as the voice-and-ear stage of language once gave way to what Walter Ong (1967) has referred to as the "chiro-... 

Vymazal J, Bulte JWM, Frank JA, di Chiro G, Brooks RA (1993) Journal of Magnetic Resonance Imaging 3 637-640... 

---