Deoxy-chiro-inositol

There are two main points of interest. First, the extent of inversion varied over a wide range, and second, the high degree of inversion found for the aminodeoxy-scyiio- (46) and 3-amino-3-deoxy-chiro-inositol acetates was in marked contrast to the predominant retention of configuration observed in the deamination of simple, equatorial amines. [Pg.38]

Deoxy-chiro-inositol 1,2-0-Isopropylidene-4-C-methyl-4-nitro- E21b, 1791 (0-SiR3-6,7-dideoxy— 2,3-O-isopropyli-den — 6-N 02 — heptofuranoside/ R4NF)... [Pg.802]

Deoxy-chiro-inositol, 9CI. Protoquerci-tol. 1,3,412,5-Cyclohexanepentol. 1-Deoxy-maco-inositol [90899-07-3]... [Pg.829]

Quercitol (= Acorn sugar 2-Deoxy-D-chiro-inositol) (cyclitol) Quercus robur (oak) (Fagaceae) [acorn], Chamaerops humilis (Palmae) [leaf], Mimusops elengii (Sapotaceae) Sweet... [Pg.404]

C6H1205 2-deoxy-D-chiro-inositol 488-73-3 13.00 1.5845 1 8845 C6H13N03 DL-2-isopropylserine 7522-43-2 25.00 1.0476 2... [Pg.225]

J. Insulin second messengers synthesis of 6-0-(2-amino-2-deoxy-a-D-glucopyrano-sylJ-D-chiro-inositol-l-phosphate. Tetrahedron, Lett., 1993, 34, 7869-7872. [Pg.116]

The preparation of inositol and structurally related phosphates continues to be actively explored. Examples include the first total synthesis of the inositol tetraphosphate enantiomeric pair, Ins(l,2,3,4)P4 (27) and Ins(l,2,3,6)P4 (28). Compounds (27) and (28) were dephosphorylated by a number of different enzymes and thus provide routes to specific inositol triphosphates. A number of myo-inositol 1,4,5-triphosphates, e.g. (29)-(32), modified at the 6-position have been prepared. All such derivatives investigated showed poor affinity for Ins(l,4,5)P3 receptors. A new and comparatively convenient synthesis of I-d-6-0-(2-amino-2-deoxy-a-D-glycopyranosyl)-chiro-inositol 1-phosphate (33) and the corresponding 1,2-cyclic phosphate (34) has been reported. The first examples of poly(ethylene glycol)-linked dimers (35) of D-myo-inositol 1,4,5-triphosphate have been prepared as probes for multi-subunit binding proteins for... [Pg.107]

D-ohiro-lnositol, 2-deoxy- 2-Deoxy-D-chiro-inositol D-1-Deoxy-muoo-inositol (- )-Protoquercitol ( )-Quercitol d-Quercitol. Sugar found in aooms. Used as a chemical intermediate. Crystals mp = 234-235° 24-26° soluble in H2O, slightly soluble in hot EtOH,... [Pg.534]

New preparative syntheses of 6-0-(2-amino-2-deoxy-a-D-glucopyranosyl)-D-chiro-inositol 1-phosphate and a 1,2-cyclic phosphate derivative have been reported. Differential protection was achieved by initially locking the four equatorial hydroxyls of D-c/iiro-inositol as cyclic Tipds ethers and then generating a ci5-epoxide from the two remaining trans-diaxial hydroxyls under Mitsunobu conditions. Lewis acid catalysed trans-diaxial opening with allyl alcohol allowed for selective protection at 0-1 and 0-6. ... [Pg.233]

Cid MB, Bonilla JB, Dumarcay S, Alonso F, Martin-Lomas M (2002) New synthesis of 1-D-0-(2-amino-2-deoxy-D-gluco- and -galactopyranosyl)-chiro- inositols. Eur J Org Chem 2002 881-888... [Pg.171]

The eplmeric IL-l-deoxy-l-C-hydroxymethyl-myo- and chiro-inositols (59) have been synthesized from an inosose derivative using a standard Wittig-hydroboration sequence to Introduce the... [Pg.168]

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