Chiral recognition molecule optimized

The optimized complex form of the chiral recognition molecule (CRM 1) of Phase 1 with (R)-acetylalanine methylester is shown in Figure 8.2. The structure optimization was performed using the MM2 program, and the... 

Combination of chiral selectors is a well-known approach in chiral EKC [2, 3, 43, 45-56], A chiral separation in CE may be decoupled in two basic steps (a) chiral recognition which occurs at the molecular level and (b) transformation of chiral recognition to a chiral separation [2], In order to design a dual chiral separation system, it is useful to analyze both of the above-mentioned steps separately. When two chiral selectors cooperate in the first (recognition) step, for instance, when a mixed complex of one analyte and two selector molecules are formed, a design of the dual system becomes almost impossible without involving additional techniques and cannot be optimized according to the below-described simplified approach [45,47]. 

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