Chiral drug separation

Cavoy E., Deltent M. E, Lehoucq S., Miggiano D. (1997) Laboratory-Developed Simulated Moving Bed for Chiral Drug Separations. Design of the System and Separation of Tramadol Enantiomers, J. Chrotnatogr. A 769 49-57. 

Enantiomers are distinguished on the basis of their interaction with a chiral selector. Development of chiral selectors or chiral stationary phases (CSPs) for GC, HPLC, and CE has rapidly opened a new dimension in the area of chiral drug separation techniques. There are different chiral selectors available for enantiomeric separation of drugs and pharmaceuticals. Finding a suitable chiral selector, whether immobilized on a solid support (GC, HPLC) or added to a running buffer (HPLC, CE), is still often based on trial and error. A few predictions can be made, however, if common structural elements are present. After a selector has been chosen, variables, such as the nature, ionic strength, and pH of buffer, can be varied, as can presence of organic modifiers, temperature, and so on. 

The main methods used for chiral drug separation are GC, HPLC, and Other techniques, such as... 

Chiral Drug Separation Table 3 Differences between HPLC and CE as chiral separation techniques 457... 

Application of Multiobjective Optimization in the Design of Chiral Drug Separators based on SMB Technology... 

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