Children ciprofloxacin

Therapeutic treatment protocol for immunocompromised persons is the same for immunocompromised adults and children Ciprofloxacin or doxycycline are first line therapeutics for all forms of anthrax... 

Cutaneous anthrax with signs of systemic involvement, extensive edema, or lesions of the head or neck require intravenous therapy, and a multidrug therapeutic approach ln children, ciprofloxacin dosage should not exceed 1 g/day... 

Children Ciprofloxacin 10-15 mg kg every 12h, or Doxycycline >8 years and >45kg 100mg every 12h >8 years and <45kg 2.2mg kg every 12h <8 years 2.2mg kg every 12h and one or two additional antimicrobials IV treatment initially. Switch to oral antimicrobial therapy when clinically appropriate Ciprofloxacin 10-15 mg kg po every 12h. or Doxycycline >8 years and >45kg lOOmg po BID >8 years and <45kg 2.2mg kg po BID <8 years 2.2mg kg po BID. Continue for 60 days (IV and po combined) ... 

If intravenous ciprofloxacin is not available, oral ciprofloxacin may be acceptable because it is rapidly and well absorbed from the gastrointestinal tract with no substantial loss by first pass metabolism. Maximum serum concentrations are attained 1-2 h after oral dosing but may not be achieved if vomiting or ileus are present In children, ciprofloxacin dosage should not exceed 1 g d ... 

Refer to source for details. In children, ciprofloxacin dose should not exceed Ig d , chloramphenicol should not exceed 4g d . Children younger than 2 years should not receive chloramphenicol... 

An acute reversible arthropathy has been described in a child with cancer treated with a short course of ciprofloxacin for febrile neutropenia (58). 

In 36 premature infants, delivered at 25-35 weeks and with birth weights of 750-2050 g, ciprofloxacin (13.8 mg/ kg/day in two or three divided doses for 3-20 days) had good efficacy in 66% of cases (62). Thrombocjdopenia (five cases), raised transaminases (three cases), hjrper-bilirubinemia (three cases), and raised creatinine concentration (two patients) were reported as adverse events one child developed femoral osteitis. 

Simpson J, Watson AR, Mellersh A, Nelson CS, Dodd K. Typhoid fever, ciprofloxacin, and renal failure. Arch Dis Child 1991 66 1083-1084. 

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