Chicken ovalbumin upstream promoter

Chou WY, Stewart MJ, Kruijer W, Crabb DW. The retinoid X receptor response element in the human aldehyde dehydrogenase 2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan receptors. Arch Biochem Biophys 2000 280 192-200. 

COUP-TFI chicken ovalbumin upstream promoter-transcription factor I... 

Abbreviations IR inverted repeat DR direct repeat ER everted repeat NR no repeat . Numbers of the HREs give the number of pairs separating the half-sites. R purine, Y pyrimidine. NGFI Nerve growth factor induced receptor COLfP-TF Chicken ovalbumin upstream promoter transcription factor ROR Retinoic acid related orphan receptor, a, P und y are receptor subtypes coded by distinct genes. After Mangelsdorf et al., 1995. 

GOUP-TF, chicken ovalbumin upstream promoter transcription factor COX, cyclooxygenase COX-1, cyclooxygenase 1 COX-2, cyclooxygenase 2, inducible cyclooxyge n ase CPA, carboxypeptidase... 

Figure 2.6. Interactions of all-frans- and 9-cw-retinoic acids (and other active retinoids) with retinoid receptors. COUP, chicken ovalbumin upstream promoter.

Nuclear receptors for the steroid hormone ecdysone in Drosophila deserve special consideration, for several reasons. First, the insect hormone ecdysone (Fig. 11.2) was the first steroid hormone shown to act at the level of the gene, because it induced puffs in the giant chromosomes of the fruitfly. Secondly, ecdysone activates the developmental programme of Drosophila, and, finally, the sequences of the DNA-binding domain (DBD) of the Drosophila nuclear ecdysone receptor and of receptor homologues (for example, the COUP-TFs chicken ovalbumin upstream promoter transcription factors) are highly conserved and nearly identical in vertebrates and humans. 

Chicken ovalbumin upstream promoter-transcription factors (COUP-TFI,n, IH)... 

Cooney, A.J., Leng, X.H., Tsai, S.Y., O Malley, B.W. Tsai, M.J. (1993). Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin-D, thyroid-hormorre, artd retinoic acid receptors. J. Biol. Chem., 268, 4152-60. 

The abbreviations used are HMG-CoA, 3-hydroxy-3-melhylglutaryl-CoA CAT, chloramphenicol acetyltransferase PPAR, peroxisome proliferator-activated receptor PPRE, peroxisome proliferator-responsive element NRRE, nuclear receptor responsive element RXR, retinoid X receptor hRXRa, human 9-cis-retinoic acid receptor a mPPARa, mouse peroxisome proliferator-activated receptor a COUP-TP, chicken ovalbumin upstream-promoter transcription factor, HNF-4, hepatocyte nuclear factor 4 EMSA, electrophoretic mobility shift analysis tk, thymidine kinase NEFA, nonesterified fatty acids... 

TREpal, palindromic TRE CRBPII, cellular retinol-binding protein II DR-1 RXRE for RXRa,Y, CPRE, chicken ovalbumin upstream promoter response element for RXR ERE, estrogen response element mLamBl, mouse laminin B1 gene RARE. 

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