Chick thyroid hormone receptors

Sjoberg, M., Vennstrom, B. Forrest, D. (1992). Thyroid hormone receptors in chick retinal development dififierential expression of mRNAs for a and N-terminal variant receptors. Development, 114, 39-47. 

A further analysis of the distribution of T3 receptors in rat cortical cells suggests a preferential localization in neurons [26,30]. A similar finding was reported in embryonic and neonatal chick brain [31]. Studies with pure cultures of neurons and astrocytes from embryonic and neonatal chick brain have confirmed the predominant localization of the receptors in neuronal nuclei [32,33]. It is clear that thyroid hormone receptors are not restricted to neuronal cells, but also appear in glial cells [34,35] suggesting that both cell types are potential targets for thyroid hormones. A direct effect of T3 on protein phosphorylation has indeed been demonstrated in neuronal and glial cells derived from rat cortex [36,37]. 

M.A. Haidar, S. Dube and P.K. Sarkar. Thyroid hormone receptors of developing chick brain are predominantly in the neurons. Biochem. Biophys. Res. Commun. 112 221-227 (1983). 

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