Chemotherapy microtubule-targeting drugs

Microtubule-targeting agents are amply used in chemotherapy and recent evidence suggests that they require of mitochondria for their anti-cancer effectiveness (Figure 6). Microtubule-destabilizing drugs such as alkaloids colchicine (used for gout treatment and familial mediterranean fever [162]) and nocodazole produce increase of free tubulin and in parallel decrease of Av /m in human hepatoma cells [163], In contrast, decrease of free tubulin... 

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