Chemotherapy dose dependent drugs

Another agent which we have used to evaluate the influence of Mn on superoxide metabolism is the antibiotic Adriamycin (ADR). Adriamycin is considered one of the most potent drugs in the field of chemotherapy, yet its clinical usefulness is compromised by a number of serious side effects including a dose-dependent cardio-toxicity. Adriamycin-induced heart disease is characterized by degeneration of the cardiac muscle mitochondria are enlarged and the intracristal spaces are substantially extended. 

Petraitis V et al. Combination therapy in treatment of experimental pulmonary aspergillosis in vitro and in vivo correlations of the concentration and dose-dependent interactions between anidulafungin and voriconazole by Bliss independence drug interaction analysts. Antimicrobial Agents and Chemotherapy. 

No drugs are known that will kill the sporozoites before they enter liver cells, in concentrations attainable after therapeutic doses at least. This is not surprising in view of the resting metabolic state of these forms of the parasite [19], since successful chemotherapy depends upon exploitation of differences between the host and parasite metabolisms. Drugs are known which will prevent erythrocytic infection, and are called causal prophylactics or primary tissue schizontocides, but they act on the asexual parasites in the liver during the pre-erythrocytic stages and before infection of reticuloendothelial cells. 

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