Chemosensor design

Of the diverse supramolecule architectures considered for chemosensor design, we emphasize one—a miniature bucket. Supramolecular buckets maintain a cylindrical cavity with structurally and chemically well-defined upper and lower rims. By virtue of its molecular shape, the bucket is an intrinsic receptor site. A supramolecular bucket alone, however, is an inadequate chemosensor because a signal cannot be produced. In the simplest chemosensing constructs, the analyte generates a signal upon association with the bucket whereas in more elaborate designs, functionality at the rim of the bucket offers sites to attach a discrete reporter site. The thematic focus of this chapter is bucket chemosensors that operate by the 3R scheme shown in Fig. 2, namely, a measurable change in a... 

A bucket-shaped cavity provides the consummate supramolecular architecture for analyte recognition. The most prominent buckets used in chemosensor design... 

Electron transfer has been reviewed extensively in recent years [183-188] and there is no need to reformulate the details of Eq. (4) here. Rather, we focus on how FC and Hda influence signal production in chemosensor design schemes. 

Many chemosensors designed by Shinkai and coworkers are based on modification of the lower rim of a calix[4]arene with a fluorophore, whose emission properties change upon association of alkali metal cations. Fluorescence from the biphenyl subunit of 42 increases markedly upon the association of Na+... 

The dependence of electron and energy transfer rate constants on distance presents a valuable tool in chemosensor design. Large changes in the inten-... 

Binding a Molecular Entity with Selectivity. While much of organic chemistry focusses on the selective creation of covalent bonds, such irreversible associations of potential analytes yield chemodosimeters (designed for cumulative assay) in contrast to chemosensors (designed for real-time assay). Thus, sensing applications require the existence of receptors (hosts) that associate with analytes (guests) selectively and reversibly. 

Shults, M.D., Carrico-Moniz, D., and Imperiali, B. (2006) Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases. Anal. Biochem., 352, 198-207. 

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