Chemokine hematopoietic function

The properties and functions of chemokines were initially elucidated based on then-effects on the hematopoietic system, and their functions in the nervous system were not originally appreciated. Interestingly, the very first observation indicating that... 

Stem cell therapy involves infusion of specialized cells utilized to perform specific functions. The traditional use of cell therapy includes harvest and cryopreservation of autologous hematopoietic cells either from the bone marrow (old approach) or mobilization and pheresis of hematopoietic stem cells from peripheral blood using stem cell-mobilizing cytokines such as hematopoietic colony-stimulating factors (G-CSF, GM-CSF) or chemokine inhibitors (AMD-3100). A more recent stem cell source is umbilical cord blood that has rich pleuripotent potential and can engraft at lower doses than bone marrow or mobilized peripheral blood stem cells. 

Several of the new chemokines—MPIF-1, MPIF-2, LARC, and SLC—have been shown to be not only chemoattractants for leukocytes, but also inhibitors of hematopoietic progenitor-cell proli-feration. These dual functions put them in a class with several other established chemokines, including MIP-la (68), MCP-1, platelet factor (PF)-4, IL-8, and GRO-P (67). 

Chemokines and Their Receptors in Hematopoietic Cell Development and Functioning... 

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