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Chemokine-directed T lymphocyte migration

Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration... [Pg.52]

Chemokines in Leukocyte Trafficking CKs are thought to be centrally involved in leukocyte trafficking and not limited to attraction of monocytes by the CC family and neutrophils by the CXC family. Other functions of the CKs include expression of adhesion molecules, especially for the lymphocytes in both the migratory response and maturation and proliferation. The selective chemoattractant qualities shown by CKs explain the directed migration of each kind of leukocyte or even of subtypes of these cells (as T and B lymphocytes, perhaps even Thl and Th2). Several studies have shown that CC CKs attract T lymphocytes and that CD45R0, memory-phenotype cells are considered to be the main responders. The results, however, have often been contradictory, and the role of lymphocyte activation and proliferation is still unclear. The CC CKs MCP-2, MCP-3, RANTES, MIP-la, MIP-lp, and MCP-1 induce significant, dose-dependent transendothelial chemotaxis of... [Pg.714]

See other pages where Chemokine-directed T lymphocyte migration is mentioned: [Pg.55]    [Pg.49]    [Pg.18]    [Pg.87]    [Pg.26]    [Pg.49]    [Pg.85]    [Pg.55]    [Pg.112]    [Pg.242]    [Pg.20]    [Pg.146]    [Pg.192]    [Pg.355]    [Pg.794]    [Pg.320]    [Pg.320]    [Pg.334]    [Pg.88]    [Pg.236]    [Pg.144]   


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