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Chemokine crystal structures

Swaminathan GJ, Holloway DE, Colvin RA, et al. Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure 2003 11 521-32. [Pg.27]

Hoover DM, Mizoue LS, Handel TM, Lubkowski J. The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement. J Biol Chem 2000 275 23187-93. [Pg.28]

Fig. 2.5. Interactions of chemokines with heparin disaccharides. (A to C) Monomeric forms of chemokines are displayed as cartoons with residues found to interact with heparin colored red. (A) Monomer of crystal structure of CCL5 (RANTES) with heparin disaccharide I-S bound (red). (B) CXCL4 (PF4) with low-molecular-weight heparin (MW <9000d). (C) CXCL8 with heparin disaccharide I-S. (D) CXCL12 (SDF-la) with heparin disaccharide I-S. (E) CCL2, human IP-10, with conserved residues from murine IP-10 highlighted. Fig. 2.5. Interactions of chemokines with heparin disaccharides. (A to C) Monomeric forms of chemokines are displayed as cartoons with residues found to interact with heparin colored red. (A) Monomer of crystal structure of CCL5 (RANTES) with heparin disaccharide I-S bound (red). (B) CXCL4 (PF4) with low-molecular-weight heparin (MW <9000d). (C) CXCL8 with heparin disaccharide I-S. (D) CXCL12 (SDF-la) with heparin disaccharide I-S. (E) CCL2, human IP-10, with conserved residues from murine IP-10 highlighted.
Fig. 9. Ribbon structures of the three IP-IO/CXCLIO tetramers. Two orthogonal views are shovm for each. The M-form is similar to the PF4/CXCL8 and MCP-1/CCL2 structures that contain elements of CXC and CC dimers. The T and H forms contain a novel 12-stranded / -sheet. Reprinted from Structure with copyright permission from Elsevier. Swaminathan, G. et al. (2003). Crystal structures of oligomeric forms of the IP-lO/CXCLlO chemokine. Structure 11, 521-532. (See Color Insert.)... Fig. 9. Ribbon structures of the three IP-IO/CXCLIO tetramers. Two orthogonal views are shovm for each. The M-form is similar to the PF4/CXCL8 and MCP-1/CCL2 structures that contain elements of CXC and CC dimers. The T and H forms contain a novel 12-stranded / -sheet. Reprinted from Structure with copyright permission from Elsevier. Swaminathan, G. et al. (2003). Crystal structures of oligomeric forms of the IP-lO/CXCLlO chemokine. Structure 11, 521-532. (See Color Insert.)...
Blaszczyk,J., Goillie, E. V., Proost, P., Damme.J. V., Opdenakker, G., Bujacz, G. D., Wang, J. M., andji, X. (2000). Gomplete crystal structure of monocyte chemotactic protein-2, a GG chemokine that interacts with multiple receptors. Biochem. 39, 14075—14081. [Pg.382]

Hence aside from their potential for development as anti-HIV medicines, this set of analogs represents a valuable toolbox that can be used to better understand chemokine structure—activity relationships, particularly now that crystal structures of chemokine—chemokine receptor complexes are becoming available (Qin et al., 2015 Burg et al., 2015). [Pg.69]

Qin, L., Kufareva, I., Holden, L. G., Wang, C., Zheng, Y., Zhao, C., et al. (2015). Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 1117—1122. [Pg.72]

The crystal structure of Evasin-1 and Evasin-3 has been determined and reveal novel protein folds. Both proteins are unrelated in amino acid sequence and in their secondary and terciary structure and interact with host chemokines presumably in different ways. The determinadon of the structure of Evasins complexed with chemokines will define the structural basis for the Evasin selectivity of chemokines. [Pg.175]

Chemokine receptors belong to the rhodopsin family of GPCRs [8]. Within this family, the crystal structures have been elucidated for cow rhodopsin (Protein Data Bank accession numbers 1F88, IHZX, IGZM, 1L9H, and 1U19) [9-12] and squid... [Pg.34]

Figure 2.2 Crystal structure of CCL17 (PDB accession number 1NR4) [78]. The secondary structural units forming the conserved chemokine fold are shown. Figure 2.2 Crystal structure of CCL17 (PDB accession number 1NR4) [78]. The secondary structural units forming the conserved chemokine fold are shown.
Crystal structures of GPCRs have shown that Class A receptors contain an amphi-pathic Hx8 that runs parallel to the membrane. The crystal structure of squid rhodopsin has shown an additional cytoplasmic Hx9 that interacts with TM6 (Figure 2.1b). The presence in chemokine receptors of the Phe side chain at position 8.50, conserved in 68% of Class A GPCR sequences, suggests a similar Hx8 as found in the crystal structures. Finally, it has been shown that a cyteine residue at the carboxyl-terminal domain of CCR5 is palmitoylated [40]. [Pg.42]

Understanding of the molecular basis of chemokine receptor activation has been aided considerably by the determination of the crystal structure of the related GPCR bovine rhodopsin (Palczewski et al., 2000), allowing... [Pg.80]


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Chemokines structures

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