Chemokine constitutive activity

Ho, H. H., Du, D., and Gershengom, M. C. (1999). The N terminus of Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity. J. Biol. Chem. 274, 31327-31332. 

Holst, P. J., Rosenkilde, M. M., Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, B., Cifire, F., Lipp, M., Schwartz, T. W., and Lira, S. A. (2001). Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. J. Clin. Invest. 108, 1789-1796. 

Rosenkilde MM. Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74. J Biol Chem 2000 275(34) 26309-15. 

Holst PJ. Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. J Clin Invest 2001 108(12) 1789-96. 

Rosenkilde MM, Schwartz TW. Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. Mol Pharmacol 2000 57(3) 602-9. 

Gdliland, C. T., Salanga, C. L., Kawamura, T., Trejo, J., Handel, T. M. (2013). The chemokine receptor CCRl is constitutively active, which leads to G protein-independent, beta-arrestin-mediated internalization. The Journal of Biological Chemistry, 288(45), 32194-32210. 

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