Chemokine and atherosclerosis

Terkeltaub R, Boisvert WA, Curtiss LK. Chemokines and atherosclerosis. Curr Opin Lipidol 1998 9(5) 397—405. 

Rollins, B. J. (2001). Chemokines and atherosclerosis What Adam Smith has to say about vascular disease. / Clin. Invest. 108, 1269-1271. 

Thus, inflammatory factors play a role at all stages of atherosclerosis in its initiation, progression, and final clinical manifestations. This new understanding of the pathophysiology of atherosclerosis has partly resulted from the study of chemokines and their receptors (4). 

The basic biology of chemokines and their receptors is well covered in Chapters 2 and 3 of this book, and we will focus hereafter upon the roles of individual chemokines and receptors in atherosclerosis. The largest amount of data on the roles of chemokines in cardiovascular disease (C VD) has been obtained from in vitro studies and murine models, which will be discussed in detail. In man, genetic polymorphisms in chemokine and chemokine-receptor genes have pointed to an important role for specific chemokines in various atherosclerotic diseases including coronary artery disease and carotid artery occlusive disease. For properties see Table 1. 

McDermott DH, Halcox JP, Schenke WH, et al. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis. Circ Res 2001 89(5) 401—407. 

Bursill CA, Channon KM, Greaves DR. The role of chemokines in atherosclerosis recent evidence from experimental models and population genetics. Curr Opin Lipidol 2004 15(2) 145-149. 

Weber C. Platelets and chemokines in atherosclerosis partners in crime. Circ Res 2005 96(6) 612-616. 

Lucas AD, Greaves DR. Atherosclerosis role of chemokines and macrophages. Expert Rev Mol Med 2001 2001 1-18. 

Wu, D., Koga, T., Martin, K. R., and Meydani, M. (1999) Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes. Atherosclerosis 147,297-307. 

Extensive research has been performed in mice to determine the factors involved in the pathogenesis of atherosclerosis (see Table 6.7). Two knock-out mouse strains were used apolipoprein E (ApoE ) mice that develop spontaneous atherosclerosis that progresses to myocardial infarction and stroke and LDL receptor (Ldlr ) mice that develop hypercholesterolemia and lesion development upon fat feeding [175]. Crossbreeding of this mice with mice that carry deletions in genes of the immune system indicate an essential role of chemokines and their receptors in the early phase of atherosclerosis (for excellent reviews, see [176, 177]). 

Chemokines, Chemokine Receptors and Atherosclerosis A. CCL2 and CCR2... 

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